Cover legend:Retinal ganglion cell layer viewed in a retina flatmount from a 9-month-old DBA/2J mouse, showing few remaining retinal ganglion cells that express γ-synuclein mRNA (red) and two retinal ganglion cells that have aberrant accumulation of phosphorylated neurofilaments (green) in their somas, one of which also has aberrant phosphorylated neurofilament accumulation in proximal portions of its axon and dendrites. Retinal ganglion cell layer nuclei are shown in blue. See the article by Soto et al. in this issue (pages548–561).