Figure 2.
Figure 2.
Gabapentin (50 μm) and ethanol additively augment IPSC amplitudes in CeA from nondependent rats. A, Pooled data from five CeA neurons show that ethanol (44 mm) coapplied with gabapentin further increased GABA-IPSC amplitudes, suggesting that gabapentin and ethanol may use different intracellular mechanisms to augment GABA-IPSCs. B, Gabapentin (50 μm) significantly (p < 0.05; n = 7) decreased the mean paired-pulse ratio, and ethanol further significantly (p < 0.05; n = 7) decreased it, with recovery on washout. Ethanol alone also significantly (*p < 0.05) decreased PPF of GABA-IPSCs (n = 6) as we have shown previously (Roberto et al., 2003). Error bars indicate SEM.
