Article Figures & Data
Figures
- Figure 1.
Mitochondrial respiration in sedentary (n = 10 of each genotype) and exercised (n = 10 of each genotype) UCP2wt and UCP2ko mice. a, State 2 respiration after addition of palmitate/malate in the respiration buffer. b, State 3 respiration induced by ADP. c, State 4, representing respiration after addition of oligomycin, an H+-transporting ATP synthase inhibitor. d, FFA-induced mitochondrial respiration. e, Total uncoupling activity after addition of FCCP. In the histograms, the y-axis units are nanomoles of O2 per minute per milligram of protein. *p < 0.05; **p < 0.01. Error bars represent SEM.
- Figure 2.
Mitochondrial number in the cell body of neurons from the dentate gyrus and CA1 of sedentary (n = 10 of each genotype) and exercised (n = 10 of each genotype) UCP2wt and UCP2ko mice. Top, Representative electron microscopic images of neuronal cell bodies with mitochondria marked in red. Bottom left, Histogram representing a quantitative analysis of mitochondrial number in cell bodies of CA1 pyramidal neurons. Bottom right, Histogram representing mitochondrial number in DG neurons. Scale bars, 1 μm. *p < 0.05; **p < 0.01. Error bars represent SEM.
- Figure 3.
Spine synapse counts of neurons from the dentate gyrus and CA1 of sedentary (n = 10 of each genotype) and exercised (n = 10 of each genotype) UCP2wt and UCP2ko mice. Top, Representative electron microscopic images of spine synapses marked in blue. Bottom left, Histogram representing a quantitative analysis of spine synapse number in CA1 pyramidal neurons. Bottom right, Histogram representing spine synapse number in DG neurons. Scale bars, 1 μm. *p < 0.05; **p < 0.01. Error bars represent SEM.
