Up-Regulation of P2X4 Receptors in Spinal Microglia after Peripheral Nerve Injury Mediates BDNF Release and Neuropathic Pain

Lauriane Ulmann; Jon P. Hatcher; Jane P. Hughes; Séverine Chaumont; Paula J. Green; François Conquet; Gary N. Buell; Alison J. Reeve; Iain P. Chessell; Francois Rassendren

doi:10.1523/JNEUROSCI.2308-08.2008

Article Information

DOI

https://doi.org/10.1523/JNEUROSCI.2308-08.2008

PubMed

18971468

Published By

Society for Neuroscience

History

Received May 21, 2008
Revision received September 9, 2008
Accepted September 22, 2008
First published October 29, 2008.

Version of record published October 29, 2008.

Author Information

Lauriane Ulmann¹,²,
Jon P. Hatcher³,
Jane P. Hughes³,
Séverine Chaumont¹,²,
Paula J. Green³,
François Conquet⁴,
Gary N. Buell⁴,
Alison J. Reeve³,
Iain P. Chessell³, and
Francois Rassendren¹,²

¹Institut de Génomique Fonctionnelle, Centre National de la Recherche Scientifique, Unité Mixte de Recherche 5203, and
²INSERM, U661, and Université Montpellier, 1, 2, 34094 Montpellier, France,
³Pain Research, Neurology and Gastrointestinal Centre of Excellence for Drug Discovery, GlaxoSmithKline, Harlow, Essex CM19 5AW, United Kingdom, and
⁴GlaxoWellcome Biomedical Research Institute, Geneva 1228, Switzerland

Correspondence should be addressed to Francois Rassendren, Institut de Génomique Fonctionnelle, CNRS UMR5203, 141 rue de la Cardonille, 34094 Montpellier, France. far{at}igh.cnrs.fr

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Author contributions

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Disclosures

Received May 21, 2008.
Revision received September 9, 2008.
Accepted September 22, 2008.

This work was supported by the Centre National de la Recherche Scientifique, the Agence Nationale de la Recherche (ANR-05-NEUR-037), the Association pour la Recherche sur le Cancer, and l'Institut UPSA de la Douleur. This work was made possible thanks to the Animal facility of Institut Fédératif de Recherche 3 and the Montpellier Réseau Inter-Organisme Imaging facility. We thank Claire Berthoud for her help with the spared nerve injury model.
Correspondence should be addressed to Francois Rassendren, Institut de Génomique Fonctionnelle, CNRS UMR5203, 141 rue de la Cardonille, 34094 Montpellier, France. far{at}igh.cnrs.fr

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	Abstract	Full	Pdf
Oct 2008	359	78	313
Nov 2008	173	254	289
Dec 2008	54	114	114
Total 2008	586	446	716
Jan 2009	40	168	118
Feb 2009	23	76	85
Mar 2009	49	77	73
Apr 2009	36	99	86
May 2009	14	102	92
Jun 2009	20	117	90
Jul 2009	16	85	66
Aug 2009	20	72	61
Sep 2009	16	65	65
Oct 2009	15	69	58
Nov 2009	27	57	55
Dec 2009	23	47	56
Total 2009	299	1034	905
Jan 2010	19	77	66
Feb 2010	29	58	51
Mar 2010	23	78	70
Apr 2010	25	52	45
May 2010	24	64	56
Jun 2010	23	74	52
Jul 2010	11	46	51
Aug 2010	16	60	49
Sep 2010	24	40	52
Oct 2010	35	60	56
Nov 2010	17	59	68
Dec 2010	25	53	56
Total 2010	271	721	672
Jan 2011	22	54	55
Feb 2011	23	45	64
Mar 2011	40	50	60
Apr 2011	35	67	68
May 2011	36	45	50
Jun 2011	35	49	46
Jul 2011	35	46	40
Aug 2011	40	40	38
Sep 2011	33	34	37
Oct 2011	39	29	30
Nov 2011	31	48	47
Dec 2011	37	31	36
Total 2011	406	538	571
Jan 2012	45	32	46
Feb 2012	44	34	46
Mar 2012	47	55	45
Apr 2012	58	54	51
May 2012	32	53	44
Jun 2012	17	37	45
Jul 2012	45	58	61
Aug 2012	32	32	29
Sep 2012	27	31	33
Oct 2012	41	30	39
Nov 2012	71	26	38
Dec 2012	44	31	32
Total 2012	503	473	509
Jan 2013	38	47	68
Feb 2013	41	36	55
Mar 2013	50	42	47
Apr 2013	39	38	42
May 2013	55	42	53
Jun 2013	43	28	38
Jul 2013	44	33	48
Aug 2013	49	42	46
Sep 2013	24	29	41
Oct 2013	52	28	59
Nov 2013	32	33	47
Dec 2013	21	23	46
Total 2013	488	421	590
Jan 2014	38	26	46
Feb 2014	46	49	62
Mar 2014	18	43	53
Apr 2014	35	40	53
May 2014	31	32	37
Jun 2014	31	51	50
Jul 2014	47	42	50
Aug 2014	28	26	33
Sep 2014	31	25	45
Oct 2014	40	30	36
Nov 2014	49	58	61
Dec 2014	26	36	48
Total 2014	420	458	574
Jan 2015	52	44	50
Feb 2015	31	51	55
Mar 2015	42	40	62
Apr 2015	30	36	55
May 2015	33	21	39
Jun 2015	26	16	33
Jul 2015	30	26	60
Aug 2015	34	35	32
Sep 2015	46	28	31
Oct 2015	38	35	44
Nov 2015	53	36	50
Dec 2015	42	33	39
Total 2015	457	401	550
Jan 2016	46	45	62
Feb 2016	31	35	33
Mar 2016	47	49	60
Apr 2016	44	33	34
May 2016	26	56	46
Jun 2016	23	32	28
Jul 2016	17	23	28
Aug 2016	18	10	24
Sep 2016	21	18	27
Oct 2016	12	28	42
Nov 2016	10	37	68
Dec 2016	10	45	20
Total 2016	305	411	472
Jan 2017	7	65	34
Feb 2017	20	44	56
Mar 2017	13	77	38
Apr 2017	11	37	20
May 2017	19	71	32
Jun 2017	8	35	27
Jul 2017	15	43	45
Aug 2017	14	42	40
Sep 2017	19	35	36
Oct 2017	9	47	25
Nov 2017	16	40	30
Dec 2017	10	29	22
Total 2017	161	565	405
Jan 2018	16	37	24
Feb 2018	22	37	29
Mar 2018	20	61	30
Apr 2018	32	52	25
May 2018	27	39	17
Jun 2018	23	34	15
Jul 2018	16	39	27
Aug 2018	7	51	20
Sep 2018	14	31	18
Oct 2018	20	64	31
Nov 2018	13	51	31
Dec 2018	17	53	26
Total 2018	227	549	293
Jan 2019	21	40	22
Feb 2019	14	56	39
Mar 2019	15	47	30
Apr 2019	15	71	25
May 2019	9	36	15
Jun 2019	13	25	21
Jul 2019	23	30	31
Aug 2019	14	50	20
Sep 2019	9	47	16
Oct 2019	13	53	18
Nov 2019	12	27	21
Dec 2019	13	25	9
Total 2019	171	507	267
Jan 2020	7	25	11
Feb 2020	10	41	16
Mar 2020	15	25	29
Apr 2020	9	22	20
May 2020	9	27	17
Jun 2020	8	27	14
Jul 2020	4	9	3
Total 2020	62	176	110
Total	4356	6700	6634