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Adult Neurogenesis, Mental Health, and Mental Illness: Hope or Hype?

Amelia J. Eisch, Heather A. Cameron, Juan M. Encinas, Leslie A. Meltzer, Guo-Li Ming and Linda S. Overstreet-Wadiche
Journal of Neuroscience 12 November 2008, 28 (46) 11785-11791; DOI: https://doi.org/10.1523/JNEUROSCI.3798-08.2008
Amelia J. Eisch
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Heather A. Cameron
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Juan M. Encinas
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Leslie A. Meltzer
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Guo-Li Ming
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Linda S. Overstreet-Wadiche
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Abstract

Psychiatric and neurologic disorders take an enormous toll on society. Alleviating the devastating symptoms and consequences of neuropsychiatric disorders such as addiction, depression, epilepsy, and schizophrenia is a main force driving clinical and basic researchers alike. By elucidating these disease neuromechanisms, researchers hope to better define treatments and preventive therapies. Research suggests that regulation of adult hippocampal neurogenesis represents a promising approach to treating and perhaps preventing mental illness. Here we appraise the role of adult hippocampal neurogenesis in major psychiatric and neurologic disorders within the essential framework of recent progress made in understanding “normal” adult neurogenesis. Topics addressed include the following: the life cycle of an adult hippocampal stem cell and the implications for aging; links between learning and hippocampal neurogenesis; the reciprocal relationship between cocaine self-administration and adult hippocampal neurogenesis; the role of adult neurogenesis in an animal model of depression and response to antidepressant exposure; the impact of neonatal seizures on dentate gyrus neurogenesis; and the contribution of a schizophrenia-susceptibility gene to adult hippocampal neurogenesis. These topics are discussed in light of the regulation of adult neurogenesis, the relationship to normal neurogenesis in adulthood and aging, and, importantly, the manipulation of neurogenesis to promote mental health and treat mental illness.

  • neural stem cell
  • epilepsy
  • learning
  • depression
  • addiction
  • schizophrenia
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The Journal of Neuroscience: 28 (46)
Journal of Neuroscience
Vol. 28, Issue 46
12 Nov 2008
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Adult Neurogenesis, Mental Health, and Mental Illness: Hope or Hype?
Amelia J. Eisch, Heather A. Cameron, Juan M. Encinas, Leslie A. Meltzer, Guo-Li Ming, Linda S. Overstreet-Wadiche
Journal of Neuroscience 12 November 2008, 28 (46) 11785-11791; DOI: 10.1523/JNEUROSCI.3798-08.2008

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Adult Neurogenesis, Mental Health, and Mental Illness: Hope or Hype?
Amelia J. Eisch, Heather A. Cameron, Juan M. Encinas, Leslie A. Meltzer, Guo-Li Ming, Linda S. Overstreet-Wadiche
Journal of Neuroscience 12 November 2008, 28 (46) 11785-11791; DOI: 10.1523/JNEUROSCI.3798-08.2008
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  • Article
    • Abstract
    • Introduction
    • The life cycle of an adult hippocampus neural stem cell: implications for aging
    • Links between learning and adult hippocampal neurogenesis
    • Addicted to neurogenesis: do new hippocampal neurons regulate cocaine self-administration?
    • The neurogenesis hypothesis of depression revisited: distinct roles for newborn neurons in the neurophysiology of depression and its treatment
    • Seizing the network: integration of newborn neurons in epileptogenesis
    • The schizophrenia susceptibility gene DISC1 regulates adult hippocampal neurogenesis
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