Article Figures & Data
Figures
- Figure 1.
Calcium-stimulated adenylyl cyclase activity is altered in the anterior cingulate cortex (ACC) from AC1−/− ( a ) and AC1+ ( b ) mice. Samples taken from mice at 3 and 9 months of age were assayed for adenylyl cyclase activity in the absence (basal) or presence of 5 μm free calcium (+ Calcium) as described in Materials and Methods. WT = wild-type littermate mice. Error bars are SEM.
- Figure 2.
AC1 activity is critical for the persistence of remote contextual memory. Mice were trained for contextual memory and tested at various times after training as described in Materials and Methods. a , AC1−/− and wild-type littermate mice were trained by allowing them to explore for 2 min after which they received a 0.7 mA, 2 s foot shock from the metal grid floor. b , Older AC1−/− mice (19-week-old or 40-week-old) were trained as in a and tested for contextual memory 1 d later. c , AC1−/− mice were trained as described in a while wild-type littermates were trained with a weak training paradigm (0.5 min to explore followed by a 0.2 mA, 1 s foot shock). d , AC1+ and their wild-type littermates mice were trained for context (2 min exploration, 0.7 mA, 2 s foot shock) and tested for contextual memory at several times after training. n = 8 mice in each group in all panels except the 40-week-old group with n = 6; *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0004. Error bars are SEM.
- Figure 3.
Extinction of remote contextual memory does not depend on AC1 activity. AC1−/− and wild-type littermate mice, trained for contextual memory, were returned to the training apparatus 3 weeks after training to assess extinction of fear memory. Extinction of remote contextual memory is not altered in AC1−/− mice. n = 8 mice in each group. Error bars are SEM.
