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Articles, Neurobiology of Disease

Targeted Disruption of Na+/Ca2+ Exchanger 3 (NCX3) Gene Leads to a Worsening of Ischemic Brain Damage

Pasquale Molinaro, Ornella Cuomo, Giuseppe Pignataro, Francesca Boscia, Rossana Sirabella, Anna Pannaccione, Agnese Secondo, Antonella Scorziello, Annagrazia Adornetto, Rosaria Gala, Davide Viggiano, Sophie Sokolow, Andre Herchuelz, Stèphane Schurmans, Gianfranco Di Renzo and Lucio Annunziato
Journal of Neuroscience 30 January 2008, 28 (5) 1179-1184; DOI: https://doi.org/10.1523/JNEUROSCI.4671-07.2008
Pasquale Molinaro
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Ornella Cuomo
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Giuseppe Pignataro
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Francesca Boscia
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Rossana Sirabella
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Anna Pannaccione
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Agnese Secondo
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Antonella Scorziello
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Annagrazia Adornetto
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Rosaria Gala
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Davide Viggiano
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Sophie Sokolow
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Andre Herchuelz
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Stèphane Schurmans
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Gianfranco Di Renzo
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Lucio Annunziato
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Article Information

DOI 
https://doi.org/10.1523/JNEUROSCI.4671-07.2008
PubMed 
18234895
Published By 
Society for Neuroscience
History 
  • Received July 6, 2007
  • Revision received December 5, 2007
  • Accepted December 6, 2007
  • First published January 30, 2008.
  • Version of record published January 30, 2008.
Copyright & Usage 
Copyright © 2008 Society for Neuroscience 0270-6474/08/281179-06$15.00/0

Author Information

  1. Pasquale Molinaro1,*,
  2. Ornella Cuomo1,*,
  3. Giuseppe Pignataro1,*,
  4. Francesca Boscia1,*,
  5. Rossana Sirabella1,
  6. Anna Pannaccione1,
  7. Agnese Secondo1,
  8. Antonella Scorziello1,
  9. Annagrazia Adornetto1,
  10. Rosaria Gala1,
  11. Davide Viggiano1,
  12. Sophie Sokolow2,
  13. Andre Herchuelz2,
  14. Stèphane Schurmans3,
  15. Gianfranco Di Renzo1, and
  16. Lucio Annunziato1
  1. 1Division of Pharmacology, Department of Neuroscience, School of Medicine, “Federico II” University of Naples, 80131 Naples, Italy,
  2. 2Laboratory of Pharmacology and Therapeutics, and
  3. 3Institut de Recherches en Biologie Humaine et Moléculaire-Institut de Biologie et de Médecine Moléculaires, Université Libre de Bruxelles, 6041 Gosselies, Belgium
  1. Correspondence should be addressed to Dr. Lucio Annunziato, Division of Pharmacology, Department of Neuroscience, School of Medicine, “Federico II” University of Naples, Via Pansini 5, 80131 Naples, Italy. lannunzi{at}unina.it
  • S. Sokolow's present address: University of California, Los Angeles School of Nursing, Los Angeles, CA 90095.

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Author contributions

  • S. Sokolow's present address: University of California, Los Angeles School of Nursing, Los Angeles, CA 90095.

  1. ↵*P.M., O.C., G.P., and F.B. contributed equally to this work.

Disclosures

    • Received July 6, 2007.
    • Revision received December 5, 2007.
    • Accepted December 6, 2007.
  • This work was supported by grants from COFIN 2006, Regione Campania GEAR, Ricerca Finalizzata Ministero della Salute Legge 502/92 “Geni Vulnerabiltà e di Riparazione DNA,” Legge 5/2003, and by “Ministero Affari Esteri, Direzione Generale per la Promozione e la Cooperazione Culturale Fondi Italia-Cina Legge 401/1990 2007” (all to L.A.). We thank Prof. K. D. Philipson and Dr. D. A. Nicoll (University of California, Los Angeles) for providing us anti-NCX3 antibody, Drs. Guido Laccarino and Alfonso Campanile for helping us with measuring MABP, Dr. Paola Merolla for the editorial revision, and Vincenzo Grillo and Carmine Capitale for the technical support.

  • Correspondence should be addressed to Dr. Lucio Annunziato, Division of Pharmacology, Department of Neuroscience, School of Medicine, “Federico II” University of Naples, Via Pansini 5, 80131 Naples, Italy. lannunzi{at}unina.it

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The Journal of Neuroscience: 28 (5)
Journal of Neuroscience
Vol. 28, Issue 5
30 Jan 2008
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Targeted Disruption of Na+/Ca2+ Exchanger 3 (NCX3) Gene Leads to a Worsening of Ischemic Brain Damage
Pasquale Molinaro, Ornella Cuomo, Giuseppe Pignataro, Francesca Boscia, Rossana Sirabella, Anna Pannaccione, Agnese Secondo, Antonella Scorziello, Annagrazia Adornetto, Rosaria Gala, Davide Viggiano, Sophie Sokolow, Andre Herchuelz, Stèphane Schurmans, Gianfranco Di Renzo, Lucio Annunziato
Journal of Neuroscience 30 January 2008, 28 (5) 1179-1184; DOI: 10.1523/JNEUROSCI.4671-07.2008

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Targeted Disruption of Na+/Ca2+ Exchanger 3 (NCX3) Gene Leads to a Worsening of Ischemic Brain Damage
Pasquale Molinaro, Ornella Cuomo, Giuseppe Pignataro, Francesca Boscia, Rossana Sirabella, Anna Pannaccione, Agnese Secondo, Antonella Scorziello, Annagrazia Adornetto, Rosaria Gala, Davide Viggiano, Sophie Sokolow, Andre Herchuelz, Stèphane Schurmans, Gianfranco Di Renzo, Lucio Annunziato
Journal of Neuroscience 30 January 2008, 28 (5) 1179-1184; DOI: 10.1523/JNEUROSCI.4671-07.2008
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