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Brief Communications

Working Memory Capacity Predicts Dopamine Synthesis Capacity in the Human Striatum

Roshan Cools, Sasha E. Gibbs, Asako Miyakawa, William Jagust and Mark D'Esposito
Journal of Neuroscience 30 January 2008, 28 (5) 1208-1212; https://doi.org/10.1523/JNEUROSCI.4475-07.2008
Roshan Cools
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Sasha E. Gibbs
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Asako Miyakawa
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William Jagust
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Mark D'Esposito
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Abstract

Evidence from psychopharmacological research has revealed that dopamine receptor agents have opposite effects on cognitive function depending on baseline levels of working memory capacity. These contrasting effects have been interpreted to reflect differential baseline levels of dopamine. Here we demonstrate for the first time that working memory capacity as measured by listening span predicts dopamine synthesis capacity in the striatum, indicating that subjects with low working memory capacity have low DA synthesis capacity in the striatum, whereas subjects with high working memory capacity have high DA synthesis capacity in the striatum.

  • dopamine
  • working memory
  • striatum
  • listening span
  • PET
  • cognition
  • prefrontal cortex
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The Journal of Neuroscience: 28 (5)
Journal of Neuroscience
Vol. 28, Issue 5
30 Jan 2008
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Working Memory Capacity Predicts Dopamine Synthesis Capacity in the Human Striatum
Roshan Cools, Sasha E. Gibbs, Asako Miyakawa, William Jagust, Mark D'Esposito
Journal of Neuroscience 30 January 2008, 28 (5) 1208-1212; DOI: 10.1523/JNEUROSCI.4475-07.2008

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Working Memory Capacity Predicts Dopamine Synthesis Capacity in the Human Striatum
Roshan Cools, Sasha E. Gibbs, Asako Miyakawa, William Jagust, Mark D'Esposito
Journal of Neuroscience 30 January 2008, 28 (5) 1208-1212; DOI: 10.1523/JNEUROSCI.4475-07.2008
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