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Brief Communications

Working Memory Capacity Predicts Dopamine Synthesis Capacity in the Human Striatum

Roshan Cools, Sasha E. Gibbs, Asako Miyakawa, William Jagust and Mark D'Esposito
Journal of Neuroscience 30 January 2008, 28 (5) 1208-1212; https://doi.org/10.1523/JNEUROSCI.4475-07.2008
Roshan Cools
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Sasha E. Gibbs
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Asako Miyakawa
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William Jagust
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Mark D'Esposito
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    Figure 1.

    The correlation between listening span and Ki values from the left caudate nucleus.

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    Figure 2.

    The mean raw axial (MR coregistered) whole-brain FMT PET Ki images from the high-span group (left) and from the low-span group (right) overlaid on a normalized MR image. Data represent Ki values. The right is right according to neurological conventions.

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    Table 1.

    Neuropsychological data

    TestLow-spanHigh-span
    Listening span*2.8 (0.6)4.0 (0.0)
    Age21.5 (0.8)23.0 (2.8)
    NAART errors13 (1.4)11 (3.2)
    BDI2.5 (2.0)6.2 (4.0)
    Forward digit span8.8 (1.5)10.4 (1.7)
    Spatial span20.6 (3.2)22.6 (0.9)
    WCST, % perseverative errors6.8 (2.1)7.0 (0.8)
    WCST, % nonperseverative errors8.8 (4.2)5.8 (2.1)
    Letter fluency43.0 (8.6)48.8 (7.1)
    MoCA28.0 (2.0)28.8 (1.1)
    Barratt score60.2 (15.4)74.0 (12.6)
    • ↵*Significantly different between the low- and high-span groups. There were no significant differences in performance on any of the background measures. NAART, North American Adult Reading Test (Nelson, 1982); BDI, Beck Depression Inventory (Beck et al., 1961); WCST, Wisconsin Card Sorting Test (Grant and Berg, 1948); MoCA, Montreal Cognitive Assessment (Nasreddine et al., 2005).

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The Journal of Neuroscience: 28 (5)
Journal of Neuroscience
Vol. 28, Issue 5
30 Jan 2008
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Working Memory Capacity Predicts Dopamine Synthesis Capacity in the Human Striatum
Roshan Cools, Sasha E. Gibbs, Asako Miyakawa, William Jagust, Mark D'Esposito
Journal of Neuroscience 30 January 2008, 28 (5) 1208-1212; DOI: 10.1523/JNEUROSCI.4475-07.2008

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Working Memory Capacity Predicts Dopamine Synthesis Capacity in the Human Striatum
Roshan Cools, Sasha E. Gibbs, Asako Miyakawa, William Jagust, Mark D'Esposito
Journal of Neuroscience 30 January 2008, 28 (5) 1208-1212; DOI: 10.1523/JNEUROSCI.4475-07.2008
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