Skip to main content

Main menu

  • HOME
  • CONTENT
    • Early Release
    • Featured
    • Current Issue
    • Issue Archive
    • Collections
    • Podcast
  • ALERTS
  • FOR AUTHORS
    • Information for Authors
    • Fees
    • Journal Clubs
    • eLetters
    • Submit
    • Special Collections
  • EDITORIAL BOARD
    • Editorial Board
    • ECR Advisory Board
    • Journal Staff
  • ABOUT
    • Overview
    • Advertise
    • For the Media
    • Rights and Permissions
    • Privacy Policy
    • Feedback
    • Accessibility
  • SUBSCRIBE

User menu

  • Log out
  • Log in
  • My Cart

Search

  • Advanced search
Journal of Neuroscience
  • Log out
  • Log in
  • My Cart
Journal of Neuroscience

Advanced Search

Submit a Manuscript
  • HOME
  • CONTENT
    • Early Release
    • Featured
    • Current Issue
    • Issue Archive
    • Collections
    • Podcast
  • ALERTS
  • FOR AUTHORS
    • Information for Authors
    • Fees
    • Journal Clubs
    • eLetters
    • Submit
    • Special Collections
  • EDITORIAL BOARD
    • Editorial Board
    • ECR Advisory Board
    • Journal Staff
  • ABOUT
    • Overview
    • Advertise
    • For the Media
    • Rights and Permissions
    • Privacy Policy
    • Feedback
    • Accessibility
  • SUBSCRIBE
PreviousNext
Articles, Neurobiology of Disease

Hereditary Spastic Paraplegia-Associated Mutations in the NIPA1 Gene and Its Caenorhabditis elegans Homolog Trigger Neural Degeneration In Vitro and In Vivo through a Gain-of-Function Mechanism

Jiali Zhao, Dawn S. Matthies, Emmanuel J. Botzolakis, Robert L. Macdonald, Randy D. Blakely and Peter Hedera
Journal of Neuroscience 17 December 2008, 28 (51) 13938-13951; https://doi.org/10.1523/JNEUROSCI.4668-08.2008
Jiali Zhao
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Dawn S. Matthies
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Emmanuel J. Botzolakis
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Robert L. Macdonald
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Randy D. Blakely
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Peter Hedera
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • Article
  • Figures & Data
  • Info & Metrics
  • eLetters
  • PDF
Loading

Article Information

DOI 
https://doi.org/10.1523/JNEUROSCI.4668-08.2008
PubMed 
19091982
Published By 
Society for Neuroscience
History 
  • Received September 29, 2008
  • Revision received November 3, 2008
  • Accepted November 10, 2008
  • First published December 17, 2008.
  • Version of record published December 17, 2008.
Copyright & Usage 
Copyright © 2008 Society for Neuroscience 0270-6474/08/2813938-14$15.00/0

Author Information

  1. Jiali Zhao1,*,
  2. Dawn S. Matthies2,*,
  3. Emmanuel J. Botzolakis3,
  4. Robert L. Macdonald1,2,4,
  5. Randy D. Blakely2,4,5, and
  6. Peter Hedera1,4,6
  1. Departments of 1Neurology and
  2. 2Pharmacology,
  3. 3Program in Neuroscience,
  4. 4Center for Molecular Neuroscience,
  5. 5Department of Psychiatry, and
  6. 6Center for Human Genetics Research, Vanderbilt University, Nashville, Tennessee 37232-8552
  1. Correspondence should be addressed to Peter Hedera, Department of Neurology, Vanderbilt University, 465 21st Avenue South, 6140 MRB III, Nashville, TN 37232-8552. peter.hedera{at}vanderbilt.edu
View Full Text

Author contributions

  1. ↵*J.Z. and D.S.M. contributed equally to this work.

Disclosures

    • Received September 29, 2008.
    • Revision received November 3, 2008.
    • Accepted November 10, 2008.
  • This work was supported by National Institutes of Health (NIH) Grant K08NS42743 and by the Spastic Paraplegia Foundation to P.H. D.S.M. and R.D.B. are supported by NIH Grant R37MH073159. We gratefully acknowledge the use of the Worm Core Facility of the Center for Molecular Neuroscience (Vanderbilt University Medical Center) and the Vanderbilt University Medical Center Cell Imaging Core Resource. The Vanderbilt University Medical Center Cell Imaging Core Resource is supported by NIH Grants CA68485 and DK20593.

  • Correspondence should be addressed to Peter Hedera, Department of Neurology, Vanderbilt University, 465 21st Avenue South, 6140 MRB III, Nashville, TN 37232-8552. peter.hedera{at}vanderbilt.edu

Online Impact

 

Article usage

Select a custom date range for the past year
E.g., 2025-07-10
to
E.g., 2025-07-10

Article usage: January 2018 to July 2025

AbstractFullPdf
Jan 20183252
Feb 2018264
Mar 20182287
Apr 20183121
May 20181143
Jun 20182132
Jul 20182122
Aug 2018290
Sep 20182154
Oct 20180140
Nov 20182185
Dec 20181175
Total 20182218335
Jan 20191132
Feb 2019282
Mar 20193158
Apr 2019498
May 20193169
Jun 20190114
Jul 20193178
Aug 2019183
Oct 20191183
Nov 20194168
Dec 20190142
Total 20192214557
Jan 20202256
Feb 20202195
Mar 20202176
May 20202194
Jun 20202137
Jul 20203194
Aug 202001614
Sep 20200209
Oct 202072315
Nov 202010287
Dec 20204329
Total 20203423186
Jan 20214209
Feb 20212145
Mar 202193325
Apr 20212303
May 20213185
Jun 20211132
Jul 20211129
Aug 202121515
Sep 202162620
Oct 202122319
Nov 202161815
Dec 20212214
Total 202140243131
Jan 2022204236
Feb 20226328
Mar 20221198
Apr 20222223
May 202222218
Jun 202231611
Jul 20223109
Aug 20224155
Sep 202221713
Oct 20223177
Nov 2022066
Dec 20222128
Total 202248230132
Jan 2023133217
Feb 20232128
Mar 202353910
Apr 20231113
May 20231148
Jun 20232224
Jul 20232119
Aug 20232147
Sep 20233189
Oct 20231219
Nov 202331310
Dec 20234197
Total 202339226101
Jan 202422914
Feb 20244227
Mar 20242158
Apr 202451058
May 20241187
Jun 20240137
Jul 20241129
Aug 20242209
Sep 2024069
Oct 202421297
Nov 20248345
Dec 202433312
Total 202430436102
Jan 202563116
Feb 20254339
Mar 20255386
Apr 202523111
May 202532611
Jun 20252146
Jul 2025430
Total 20252617659
Total2611870703
Back to top

In this issue

The Journal of Neuroscience: 28 (51)
Journal of Neuroscience
Vol. 28, Issue 51
17 Dec 2008
  • Table of Contents
  • Table of Contents (PDF)
  • About the Cover
  • Index by author
Email

Thank you for sharing this Journal of Neuroscience article.

NOTE: We request your email address only to inform the recipient that it was you who recommended this article, and that it is not junk mail. We do not retain these email addresses.

Enter multiple addresses on separate lines or separate them with commas.
Hereditary Spastic Paraplegia-Associated Mutations in the NIPA1 Gene and Its Caenorhabditis elegans Homolog Trigger Neural Degeneration In Vitro and In Vivo through a Gain-of-Function Mechanism
(Your Name) has forwarded a page to you from Journal of Neuroscience
(Your Name) thought you would be interested in this article in Journal of Neuroscience.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
Print
View Full Page PDF
Citation Tools
Hereditary Spastic Paraplegia-Associated Mutations in the NIPA1 Gene and Its Caenorhabditis elegans Homolog Trigger Neural Degeneration In Vitro and In Vivo through a Gain-of-Function Mechanism
Jiali Zhao, Dawn S. Matthies, Emmanuel J. Botzolakis, Robert L. Macdonald, Randy D. Blakely, Peter Hedera
Journal of Neuroscience 17 December 2008, 28 (51) 13938-13951; DOI: 10.1523/JNEUROSCI.4668-08.2008

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero
Respond to this article
Request Permissions
Share
Hereditary Spastic Paraplegia-Associated Mutations in the NIPA1 Gene and Its Caenorhabditis elegans Homolog Trigger Neural Degeneration In Vitro and In Vivo through a Gain-of-Function Mechanism
Jiali Zhao, Dawn S. Matthies, Emmanuel J. Botzolakis, Robert L. Macdonald, Randy D. Blakely, Peter Hedera
Journal of Neuroscience 17 December 2008, 28 (51) 13938-13951; DOI: 10.1523/JNEUROSCI.4668-08.2008
Twitter logo Facebook logo Mendeley logo
  • Tweet Widget
  • Facebook Like
  • Google Plus One

Jump to section

  • Article
    • Abstract
    • Introduction
    • Materials and Methods
    • Results
    • Discussion
    • Footnotes
    • References
  • Figures & Data
  • Info & Metrics
  • eLetters
  • PDF

Responses to this article

Respond to this article

Jump to comment:

No eLetters have been published for this article.

Related Articles

Cited By...

More in this TOC Section

Articles

  • Memory Retrieval Has a Dynamic Influence on the Maintenance Mechanisms That Are Sensitive to ζ-Inhibitory Peptide (ZIP)
  • Neurophysiological Evidence for a Cortical Contribution to the Wakefulness-Related Drive to Breathe Explaining Hypocapnia-Resistant Ventilation in Humans
  • Monomeric Alpha-Synuclein Exerts a Physiological Role on Brain ATP Synthase
Show more Articles

Neurobiology of Disease

  • Unveiling cortical criticality changes along the prodromal to the overt continuum of alpha-synucleinopathy
  • Atypical Retinal Ganglion Cell Function in a Mouse Model of Fragile X Syndrome
  • Basal forebrain-ventral tegmental area glutamatergic pathway promotes emergence from isoflurane anesthesia in mice
Show more Neurobiology of Disease
  • Home
  • Alerts
  • Follow SFN on BlueSky
  • Visit Society for Neuroscience on Facebook
  • Follow Society for Neuroscience on Twitter
  • Follow Society for Neuroscience on LinkedIn
  • Visit Society for Neuroscience on Youtube
  • Follow our RSS feeds

Content

  • Early Release
  • Current Issue
  • Issue Archive
  • Collections

Information

  • For Authors
  • For Advertisers
  • For the Media
  • For Subscribers

About

  • About the Journal
  • Editorial Board
  • Privacy Notice
  • Contact
  • Accessibility
(JNeurosci logo)
(SfN logo)

Copyright © 2025 by the Society for Neuroscience.
JNeurosci Online ISSN: 1529-2401

The ideas and opinions expressed in JNeurosci do not necessarily reflect those of SfN or the JNeurosci Editorial Board. Publication of an advertisement or other product mention in JNeurosci should not be construed as an endorsement of the manufacturer’s claims. SfN does not assume any responsibility for any injury and/or damage to persons or property arising from or related to any use of any material contained in JNeurosci.