Cover legend: Multiphoton reconstruction of cortical microglia in a 3.5-month-old double-transgenic (PDAPP+/−; CX3CR1/GFP+/−) mouse, which developed amyloid plaques and expressed GFP specifically in microglia. Vessels were filled with Texas Red dextran. For more information, see the article by Koenigsknecht-Talboo et al. in this issue (pages 14156–14164).