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Articles, Behavioral/Systems/Cognitive

Mesolimbic Functional Magnetic Resonance Imaging Activations during Reward Anticipation Correlate with Reward-Related Ventral Striatal Dopamine Release

Björn H. Schott, Luciano Minuzzi, Ruth M. Krebs, David Elmenhorst, Markus Lang, Oliver H. Winz, Constanze I. Seidenbecher, Heinz H. Coenen, Hans-Jochen Heinze, Karl Zilles, Emrah Düzel and Andreas Bauer
Journal of Neuroscience 24 December 2008, 28 (52) 14311-14319; DOI: https://doi.org/10.1523/JNEUROSCI.2058-08.2008
Björn H. Schott
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Luciano Minuzzi
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Ruth M. Krebs
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David Elmenhorst
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Markus Lang
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Oliver H. Winz
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Constanze I. Seidenbecher
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Heinz H. Coenen
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Hans-Jochen Heinze
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Karl Zilles
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Emrah Düzel
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Andreas Bauer
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Abstract

The dopaminergic mechanisms that control reward-motivated behavior are the subject of intense study, but it is yet unclear how, in humans, neural activity in mesolimbic reward-circuitry and its functional neuroimaging correlates are related to dopamine release. To address this question, we obtained functional magnetic resonance imaging (fMRI) measures of reward-related neural activity and [11C]raclopride positron emission tomography measures of dopamine release in the same human participants, while they performed a delayed monetary incentive task. Across the cohort, a positive correlation emerged between neural activity of the substantia nigra/ventral tegmental area (SN/VTA), the main origin of dopaminergic neurotransmission, during reward anticipation and reward-related [11C]raclopride displacement as an index of dopamine release in the ventral striatum, major target of SN/VTA dopamine neurons. Neural activity in the ventral striatum/nucleus accumbens itself also correlated with ventral striatal dopamine release. Additionally, high-reward-related dopamine release was associated with increased activation of limbic structures, such as the amygdala and the hippocampus. The observed correlations of reward-related mesolimbic fMRI activation and dopamine release provide evidence that dopaminergic neurotransmission plays a quantitative role in human mesolimbic reward processing. Moreover, the combined neurochemical and hemodynamic imaging approach used here opens up new perspectives for the investigation of molecular mechanisms underlying human cognition.

  • dopamine
  • fMRI
  • reward
  • midbrain
  • substantia nigra
  • nucleus accumbens
  • neurotransmission
  • receptor
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The Journal of Neuroscience: 28 (52)
Journal of Neuroscience
Vol. 28, Issue 52
24 Dec 2008
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Mesolimbic Functional Magnetic Resonance Imaging Activations during Reward Anticipation Correlate with Reward-Related Ventral Striatal Dopamine Release
Björn H. Schott, Luciano Minuzzi, Ruth M. Krebs, David Elmenhorst, Markus Lang, Oliver H. Winz, Constanze I. Seidenbecher, Heinz H. Coenen, Hans-Jochen Heinze, Karl Zilles, Emrah Düzel, Andreas Bauer
Journal of Neuroscience 24 December 2008, 28 (52) 14311-14319; DOI: 10.1523/JNEUROSCI.2058-08.2008

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Mesolimbic Functional Magnetic Resonance Imaging Activations during Reward Anticipation Correlate with Reward-Related Ventral Striatal Dopamine Release
Björn H. Schott, Luciano Minuzzi, Ruth M. Krebs, David Elmenhorst, Markus Lang, Oliver H. Winz, Constanze I. Seidenbecher, Heinz H. Coenen, Hans-Jochen Heinze, Karl Zilles, Emrah Düzel, Andreas Bauer
Journal of Neuroscience 24 December 2008, 28 (52) 14311-14319; DOI: 10.1523/JNEUROSCI.2058-08.2008
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