Skip to main content

Main menu

  • HOME
  • CONTENT
    • Early Release
    • Featured
    • Current Issue
    • Issue Archive
    • Collections
    • Podcast
  • ALERTS
  • FOR AUTHORS
    • Information for Authors
    • Fees
    • Journal Clubs
    • eLetters
    • Submit
  • EDITORIAL BOARD
  • ABOUT
    • Overview
    • Advertise
    • For the Media
    • Rights and Permissions
    • Privacy Policy
    • Feedback
  • SUBSCRIBE

User menu

  • Log in
  • My Cart

Search

  • Advanced search
Journal of Neuroscience
  • Log in
  • My Cart
Journal of Neuroscience

Advanced Search

Submit a Manuscript
  • HOME
  • CONTENT
    • Early Release
    • Featured
    • Current Issue
    • Issue Archive
    • Collections
    • Podcast
  • ALERTS
  • FOR AUTHORS
    • Information for Authors
    • Fees
    • Journal Clubs
    • eLetters
    • Submit
  • EDITORIAL BOARD
  • ABOUT
    • Overview
    • Advertise
    • For the Media
    • Rights and Permissions
    • Privacy Policy
    • Feedback
  • SUBSCRIBE
PreviousNext
Brief Communications

Beyond Feeling: Chronic Pain Hurts the Brain, Disrupting the Default-Mode Network Dynamics

Marwan N. Baliki, Paul Y. Geha, A. Vania Apkarian and Dante R. Chialvo
Journal of Neuroscience 6 February 2008, 28 (6) 1398-1403; DOI: https://doi.org/10.1523/JNEUROSCI.4123-07.2008
Marwan N. Baliki
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Paul Y. Geha
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
A. Vania Apkarian
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Dante R. Chialvo
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • Article
  • Figures & Data
  • Info & Metrics
  • eLetters
  • PDF
Loading

Article Information

DOI 
https://doi.org/10.1523/JNEUROSCI.4123-07.2008
PubMed 
18256259
Published By 
Society for Neuroscience
History 
  • Received September 7, 2007
  • Revision received December 19, 2007
  • Accepted December 21, 2007
  • First published February 6, 2008.
  • Version of record published February 6, 2008.
Copyright & Usage 
Copyright © 2008 Society for Neuroscience 0270-6474/08/281398-06$15.00/0

Author Information

  1. Marwan N. Baliki1,
  2. Paul Y. Geha1,
  3. A. Vania Apkarian1,2,3,4, and
  4. Dante R. Chialvo1
  1. Departments of 1Physiology,
  2. 2Anesthesia, and
  3. 3Surgery, and
  4. 4Lurie Cancer Center, Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611
  1. Correspondence should be addressed to Dante R. Chialvo, Department of Physiology, Northwestern University, 303 East Chicago Avenue, Chicago, IL 60611. d-chialvo{at}northwestern.edu
View Full Text

Author contributions

Disclosures

    • Received September 7, 2007.
    • Revision received December 19, 2007.
    • Accepted December 21, 2007.
  • This work was funded by the National Institutes of Health–National Institute of Neurological Disorders and Stroke. We thank Florencia Chialvo, Philip Hockberger, Seema Khan, Denis Pelli, Oscar Scremin, and Veronika Zsiros for reading this manuscript. We also thank all of the participating patients and volunteers.

  • Correspondence should be addressed to Dante R. Chialvo, Department of Physiology, Northwestern University, 303 East Chicago Avenue, Chicago, IL 60611. d-chialvo{at}northwestern.edu

Online Impact

 

Article usage

Select a custom date range for the past year
E.g., 2023-06-05
to
E.g., 2023-06-05

Article usage: January 2018 to May 2023

AbstractFullPdf
Jan 20185621251
Feb 20186836573
Mar 20187720275
Apr 20185127774
May 20186620856
Jun 20183715353
Jul 20186013891
Aug 201833127106
Sep 20184910061
Oct 201873134113
Nov 20186315984
Dec 20186815398
Total 20187012228935
Jan 20196721294
Feb 20193213678
Mar 20197314888
Apr 20198623589
May 20197315279
Jun 201944121135
Jul 20194512867
Aug 20193326151
Oct 20197518779
Nov 20196914679
Dec 20194911158
Total 20196461837897
Jan 20203711058
Feb 20204212760
Mar 20202913251
May 20204011261
Jun 2020308487
Jul 20202610741
Aug 20204410236
Sep 20205714761
Oct 20204117484
Nov 20206018293
Dec 20207514367
Total 20204811420699
Jan 20218315652
Feb 20214815369
Mar 20218015977
Apr 20216614182
May 20214315262
Jun 20212514450
Jul 20214313754
Aug 20215615968
Sep 20213615666
Oct 202157182112
Nov 20214015498
Dec 20213011139
Total 20216071804829
Jan 20224814971
Feb 20222815752
Mar 20225917383
Apr 20223722759
May 20225410873
Jun 20226311374
Jul 20223315555
Aug 2022278845
Sep 2022337437
Oct 20223410573
Nov 202293018
Dec 2022214823
Total 20224461427663
Jan 20232816558
Feb 2023279049
Mar 20234019657
Apr 20232812253
May 2023509260
Total 2023173665277
Total305493814300
Back to top

In this issue

The Journal of Neuroscience: 28 (6)
Journal of Neuroscience
Vol. 28, Issue 6
6 Feb 2008
  • Table of Contents
  • Table of Contents (PDF)
  • About the Cover
  • Index by author
Email

Thank you for sharing this Journal of Neuroscience article.

NOTE: We request your email address only to inform the recipient that it was you who recommended this article, and that it is not junk mail. We do not retain these email addresses.

Enter multiple addresses on separate lines or separate them with commas.
Beyond Feeling: Chronic Pain Hurts the Brain, Disrupting the Default-Mode Network Dynamics
(Your Name) has forwarded a page to you from Journal of Neuroscience
(Your Name) thought you would be interested in this article in Journal of Neuroscience.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
Print
View Full Page PDF
Citation Tools
Beyond Feeling: Chronic Pain Hurts the Brain, Disrupting the Default-Mode Network Dynamics
Marwan N. Baliki, Paul Y. Geha, A. Vania Apkarian, Dante R. Chialvo
Journal of Neuroscience 6 February 2008, 28 (6) 1398-1403; DOI: 10.1523/JNEUROSCI.4123-07.2008

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero
Respond to this article
Request Permissions
Share
Beyond Feeling: Chronic Pain Hurts the Brain, Disrupting the Default-Mode Network Dynamics
Marwan N. Baliki, Paul Y. Geha, A. Vania Apkarian, Dante R. Chialvo
Journal of Neuroscience 6 February 2008, 28 (6) 1398-1403; DOI: 10.1523/JNEUROSCI.4123-07.2008
del.icio.us logo Digg logo Reddit logo Twitter logo Facebook logo Google logo Mendeley logo
  • Tweet Widget
  • Facebook Like
  • Google Plus One

Jump to section

  • Article
    • Abstract
    • Introduction
    • Materials and Methods
    • Results
    • Discussion
    • Footnotes
    • References
  • Figures & Data
  • Info & Metrics
  • eLetters
  • PDF

Responses to this article

Respond to this article

Jump to comment:

  • The pain is mainly in the brain (once again)
    Patrick B. Wood
    Published on: 11 February 2008
  • Published on: (11 February 2008)
    Page navigation anchor for The pain is mainly in the brain (once again)
    The pain is mainly in the brain (once again)
    • Patrick B. Wood, Chief Medical Officer

    I have read with great interest the report by Baliki and colleagues describing increased prefrontal activity (“decreased deactivation”) during a cognitive paradigm in patients with chronic low back pain (Baliki et al., 2008). While the authors suggest their findings indicate that chronic pain alters brain function, by their own admission, study design disallows definitive mechanistic explanations. Excitatory prefronta...

    Show More

    I have read with great interest the report by Baliki and colleagues describing increased prefrontal activity (“decreased deactivation”) during a cognitive paradigm in patients with chronic low back pain (Baliki et al., 2008). While the authors suggest their findings indicate that chronic pain alters brain function, by their own admission, study design disallows definitive mechanistic explanations. Excitatory prefrontal afferents preferentially target interneurons that inhibit mesolimbic projections (Carr & Sesack, 2000), while attenuated dopaminergic activity within the striatum augments nociceptive behavior (Altier & Stewart, 1999; Saadé et al, 1997). One would therefore anticipate that a predisposition towards increased prefrontal activity (i.e. “hyperfrontality”) would produce a proportional decrease in mesolimbic activity thereby augmenting nociception and, ostensibly, placing one at increased risk for developing chronic pain. Indeed, relative increases in prefrontal activity among healthy subjects correlate with increased subjective pain ratings (Coghill et al., 2003), and clinical pain states are likewise associated with prefrontal hyperactivity (Apkarian et al, 2001; Cook et al., 2004). Conversely, the inverse relationship between prefrontal activation and mesolimbic reactivity may underlie the observation that schizophrenia, which is associated with both hypofrontality (Andreasen et al., 1997) and mesolimbic hyperactivity (Bertolino et al., 1999), is also associated with hypoalgesia (Potvin & Marchand, 2007). Thus, chronic pain might be the result of increased prefrontal activity rather than its cause.

    References

    Altier N, Stewart J (1999) The role of dopamine in the nucleus accumbens in analgesia. Life Sci. 65:2269-2287.

    Andreasen NC, O'Leary DS, Flaum M, Nopoulos P, Watkins GL, Boles Ponto LL, Hichwa RD (1997) Hypofrontality in schizophrenia: distributed dysfunctional circuits in neuroleptic-naïve patients. Lancet 349:1730- 1734.

    Apkarian AV, Thomas PS, Krauss BR, Szeverenyi NM (2001) Prefrontal cortical hyperactivity in patients with sympathetically mediated chronic pain. Neurosci Lett 311:193-197.

    Baliki MN, Geha PY, Apkarian AV, Chialvo DR (2008) Beyond feeling: chronic pain hurts the brain, disrupting the default-mode network dynamics. J Neurosci 28:1398-1403.

    Bertolino A, Knable MB, Saunders RC, Callicott JH, Kolachana B, Mattay VS, Bachevalier J, Frank JA, Egan M, Weinberger DR (1999) The relationship between dorsolateral prefrontal N-acetylaspartate measures and striatal dopamine activity in schizophrenia. Biol Psychiatry 45:660- 667.

    Carr DB, Sesack SR (2000) Projections from the rat prefrontal cortex to the ventral tegmental area: target specificity in the synaptic associations with mesoaccumbens and mesocortical neurons. J Neurosci 20:3864-3873.

    Coghill RC, McHaffie JG, Yen YF (2003) Neural correlates of interindividual differences in the subjective experience of pain. Proc Natl Acad Sci U S A. 100:8538-8542.

    Cook DB, Lange G, Ciccone DS, Liu WC, Steffener J, Natelson BH (2004) Functional imaging of pain in patients with primary fibromyalgia. J Rheumatol 31:364-378.

    Potvin S, Marchand S (2007) Hypoalgesia in schizophrenia is independent of antipsychotic drugs: A systematic quantitative review of experimental studies. Pain [in press]

    Saadé NE, Atweh SF, Bahuth NB, Jabbur SJ (1997) Augmentation of nociceptive reflexes and chronic deafferentation pain by chemical lesions of either dopaminergic terminals or midbrain dopaminergic neurons. Brain Res 751:1-12.

    Show Less
    Competing Interests: None declared.

Related Articles

Cited By...

More in this TOC Section

  • Heteromodal Cortical Areas Encode Sensory-Motor Features of Word Meaning
  • Pharmacologically Counteracting a Phenotypic Difference in Cerebellar GABAA Receptor Response to Alcohol Prevents Excessive Alcohol Consumption in a High Alcohol-Consuming Rodent Genotype
  • Neuromuscular NMDA Receptors Modulate Developmental Synapse Elimination
Show more Brief Communications
  • Home
  • Alerts
  • Visit Society for Neuroscience on Facebook
  • Follow Society for Neuroscience on Twitter
  • Follow Society for Neuroscience on LinkedIn
  • Visit Society for Neuroscience on Youtube
  • Follow our RSS feeds

Content

  • Early Release
  • Current Issue
  • Issue Archive
  • Collections

Information

  • For Authors
  • For Advertisers
  • For the Media
  • For Subscribers

About

  • About the Journal
  • Editorial Board
  • Privacy Policy
  • Contact
(JNeurosci logo)
(SfN logo)

Copyright © 2023 by the Society for Neuroscience.
JNeurosci Online ISSN: 1529-2401

The ideas and opinions expressed in JNeurosci do not necessarily reflect those of SfN or the JNeurosci Editorial Board. Publication of an advertisement or other product mention in JNeurosci should not be construed as an endorsement of the manufacturer’s claims. SfN does not assume any responsibility for any injury and/or damage to persons or property arising from or related to any use of any material contained in JNeurosci.