Figure 3.
Figure 3.
Presentation of a reward-paired cue increases ERK activation in the core and shell subregions of the NAcc. Rats experienced repeated tone-food pairings and subsequently were presented with the tone, or, for the control group, were presented with a tone that was never paired with reward. A, Trained rats presented with the tone (n = 6) expressed a greater number of pERK-immunopositive cells in the core and the shell subregions of the NAcc compared with controls (n = 5). B, C, Representative photomicrographs of pERK-stained cells in the NAcc from a trained (B) and a control rat (C). Scale bar, 100 μm. ac, Anterior commissure. *Significantly different from control at p < 0.05. All data are represented as mean ± SEM.