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Featured ArticleBrief Communications

Resting Microglia Directly Monitor the Functional State of Synapses In Vivo and Determine the Fate of Ischemic Terminals

Hiroaki Wake, Andrew J. Moorhouse, Shozo Jinno, Shinichi Kohsaka and Junichi Nabekura
Journal of Neuroscience 1 April 2009, 29 (13) 3974-3980; https://doi.org/10.1523/JNEUROSCI.4363-08.2009
Hiroaki Wake
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Andrew J. Moorhouse
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Shozo Jinno
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Shinichi Kohsaka
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Junichi Nabekura
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Article Information

DOI 
https://doi.org/10.1523/JNEUROSCI.4363-08.2009
PubMed 
19339593
Published By 
Society for Neuroscience
History 
  • Received September 12, 2008
  • Revision received October 29, 2008
  • Accepted January 26, 2009
  • First published April 1, 2009.
  • Version of record published April 1, 2009.
Copyright & Usage 
Copyright © 2009 Society for Neuroscience 0270-6474/09/293974-07$15.00/0

Author Information

  1. Hiroaki Wake 1 , 2 ,
  2. Andrew J. Moorhouse 1 , 3 ,
  3. Shozo Jinno 4 ,
  4. Shinichi Kohsaka 5 , and
  5. Junichi Nabekura 1 , 2 , 6
  1. 1Division of Homeostatic Development, National Institute of Physiological Sciences, Okazaki 444-8585, Japan,
  2. 2Core Research for Evolutional Science and Technology, Japan Science and Technology Agency, Saitama 332-0012, Japan,
  3. 3Membrane Biophysics Laboratory, School of Medical Sciences, The University of New South Wales, Sydney 2052, Australia,
  4. 4Department of Anatomy and Neurobiology, Graduate School of Medical Sciences, Kyushu University, Fukuoka 812-8582, Japan,
  5. 5Department of Neurochemistry, National Institute of Neuroscience, Kodaira, Tokyo 187-8502, Japan, and
  6. 6Department of Physiological Sciences, The Graduate School for Advanced Study (Sokendai), Hayama 240-0198, Japan
  1. Correspondence should be addressed to Prof. Junichi Nabekura, Division of Homeostatic Development, Department of Developmental Physiology, National Institute for Physiological Sciences, Okazaki 444-8585, Japan. nabekura{at}nips.ac.jp
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Author contributions

Disclosures

    • Received September 12, 2008.
    • Revision received October 29, 2008.
    • Accepted January 26, 2009.
  • This work was supported by the Core Research for Evolutional Science and Technology, Japan Science and Technology Agency, and Grants-in-Aid from Ministry of Education, Culture, Sports, Science, and Technology, Japan (J.N.). We gratefully acknowledge the support of Prof. H. Kasai at Tokyo University, Dr. T. Nemoto at National Institute for Physiological Sciences (NIPS) for the establishment of the in vivo two-photon imaging system, and the expert technical assistance of M. Yoshitomo, T. Ohba (NIPS), and Y. Hirakawa (Research Support Center, Graduate School of Medical Sciences, Kyushu University).

  • Correspondence should be addressed to Prof. Junichi Nabekura, Division of Homeostatic Development, Department of Developmental Physiology, National Institute for Physiological Sciences, Okazaki 444-8585, Japan. nabekura{at}nips.ac.jp

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May 20212730966
Jun 20211119259
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Aug 20212415351
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Total 20212862143756
Jan 20222616557
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Jun 20221617486
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Total 20222601809954
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Jul 20231016991
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Jun 20246143157
Jul 202429145430
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Total 202433927602852
Jan 202518185202
Feb 202523268255
Mar 202533233295
Apr 202521174301
May 202523172329
Jun 202523164317
Jul 202519163252
Aug 202523271393
Sep 202525237290
Oct 202522149528
Nov 20251580149
Total 202524520963311
Total20211709611375
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The Journal of Neuroscience: 29 (13)
Journal of Neuroscience
Vol. 29, Issue 13
1 Apr 2009
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Resting Microglia Directly Monitor the Functional State of Synapses In Vivo and Determine the Fate of Ischemic Terminals
Hiroaki Wake, Andrew J. Moorhouse, Shozo Jinno, Shinichi Kohsaka, Junichi Nabekura
Journal of Neuroscience 1 April 2009, 29 (13) 3974-3980; DOI: 10.1523/JNEUROSCI.4363-08.2009

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Resting Microglia Directly Monitor the Functional State of Synapses In Vivo and Determine the Fate of Ischemic Terminals
Hiroaki Wake, Andrew J. Moorhouse, Shozo Jinno, Shinichi Kohsaka, Junichi Nabekura
Journal of Neuroscience 1 April 2009, 29 (13) 3974-3980; DOI: 10.1523/JNEUROSCI.4363-08.2009
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