Cover legend: Rotary shadow electron microscopical image of a cultured wild-type hippocampal neuron. The plasma membrane was removed, allowing detailed views of the underlying cytoskeleton. Comparing cytoskeletal dynamics between wild-type neurons and neurons lacking the transcriptional regulator serum response factor reveals severe morphological alterations of neurite and growth cone architecture. See the article by Stern et al. in this issue for details (pages 4512–4518).