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Brief Communications

Frontal-Limbic White Matter Pathway Associations with the Serotonin Transporter Gene Promoter Region (5-HTTLPR) Polymorphism

Jennifer Pacheco, Christopher G. Beevers, Cristina Benavides, John McGeary, Eric Stice and David M. Schnyer
Journal of Neuroscience 13 May 2009, 29 (19) 6229-6233; https://doi.org/10.1523/JNEUROSCI.0896-09.2009
Jennifer Pacheco
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Christopher G. Beevers
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Cristina Benavides
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John McGeary
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Eric Stice
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David M. Schnyer
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    Figure 1.

    a, b, The left and right uncinate fasciculus (a), shown on a coronal slice through the PFC (left panel) and an axial slice (right panel), and the left and right posterior forceps (b) are shown projected on a standard FA map. Each subject's FA map was registered into the same standard space, MNI 152, as the POIs were created, and FA values along each path were extracted using the FSL software.

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    Figure 2.

    Scatterplots of individual FA values for frontal and temporal region of the uncinate fasciculus presented by 5-HTTLPR allele group. Regression line and 95% confidence interval is also plotted to depict the relationship between FA values and 5-HTTLPR for each region.

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    Table 1.

    Unstandardized and standardized betas, t test, variance explained, and F values for the regression models predicting FA values in the left and right frontal and temporal regions of the uncinate fasciculus and left and right posterior forceps

    Unstandardized coefficientsStandardized coefficients
    BSEβt(36)R2F(1,36)
    Left frontal uncinate fasciculus0.397.05***
        Age29.0629.060.422.99*
        Genotype−165.6155.11−0.42−3.03*
        Age × genotype−4.9213.82−0.05−0.36
    Right frontal uncinate fasciculus0.212.87*
        Age24.6711.210.372.20*
        Genotype−20.7561.80−0.05−0.34
        Age × genotype14.6115.500.160.94
    Left temporal uncinate fasciculus0.010.20
        Age6.8611.780.110.58
        Genotype17.0564.970.050.26
        Age × genotype−0.6816.30−0.01−0.04
    Right temporal uncinate fasciculus0.040.50
        Age5.6110.190.100.55
        Genotype28.0756.200.090.50
        Age × genotype11.4014.100.150.81
    Left posterior forceps0.040.42
        Age4.30516.320.050.26
        Genotype96.5690.020.191.07
        Age × genotype−5.4522.58−0.04−0.24
    Right posterior forceps0.040.47
        Age2.5319.480.020.13
        Genotype83.05107.430.130.77
        Age × genotype−21.7126.95−0.15−0.81
    • ↵*p < 0.05; ***p < 0.001.

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The Journal of Neuroscience: 29 (19)
Journal of Neuroscience
Vol. 29, Issue 19
13 May 2009
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Frontal-Limbic White Matter Pathway Associations with the Serotonin Transporter Gene Promoter Region (5-HTTLPR) Polymorphism
Jennifer Pacheco, Christopher G. Beevers, Cristina Benavides, John McGeary, Eric Stice, David M. Schnyer
Journal of Neuroscience 13 May 2009, 29 (19) 6229-6233; DOI: 10.1523/JNEUROSCI.0896-09.2009

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Frontal-Limbic White Matter Pathway Associations with the Serotonin Transporter Gene Promoter Region (5-HTTLPR) Polymorphism
Jennifer Pacheco, Christopher G. Beevers, Cristina Benavides, John McGeary, Eric Stice, David M. Schnyer
Journal of Neuroscience 13 May 2009, 29 (19) 6229-6233; DOI: 10.1523/JNEUROSCI.0896-09.2009
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