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Articles, Neurobiology of Disease

Deletion of the α7 Nicotinic Acetylcholine Receptor Gene Improves Cognitive Deficits and Synaptic Pathology in a Mouse Model of Alzheimer's Disease

Gustavo Dziewczapolski, Carolina M. Glogowski, Eliezer Masliah and Stephen F. Heinemann
Journal of Neuroscience 8 July 2009, 29 (27) 8805-8815; DOI: https://doi.org/10.1523/JNEUROSCI.6159-08.2009
Gustavo Dziewczapolski
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Carolina M. Glogowski
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Eliezer Masliah
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Stephen F. Heinemann
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Article Information

DOI 
https://doi.org/10.1523/JNEUROSCI.6159-08.2009
PubMed 
19587288
Published By 
Society for Neuroscience
History 
  • Received December 26, 2008
  • Revision received May 6, 2009
  • Accepted June 1, 2009
  • First published July 8, 2009.
  • Version of record published July 8, 2009.
Copyright & Usage 
Copyright © 2009 Society for Neuroscience 0270-6474/09/298805-11$15.00/0

Author Information

  1. Gustavo Dziewczapolski1,
  2. Carolina M. Glogowski1,
  3. Eliezer Masliah2,3, and
  4. Stephen F. Heinemann1
  1. 1Molecular Neurobiology Laboratory, The Salk Institute for Biological Studies, La Jolla, California 92037, and
  2. Departments of 2Neurosciences and
  3. 3Pathology, University of California at San Diego, La Jolla, California 92037
  1. Correspondence should be addressed to Dr. Gustavo Dziewczapolski, Molecular Neurobiology Laboratory, The Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, CA 92037. gustavo{at}salk.edu
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Author contributions

Disclosures

    • Received December 26, 2008.
    • Revision received May 6, 2009.
    • Accepted June 1, 2009.
  • This work was supported in part by National Institutes of Health/National Institute of Aging Grant 5 P01 AG010435-16 (S.F.H. and E.M.), Bundy Foundation (G.D.), and the Ellison Medical Foundation (S.F.H). We thank Dr. Lennart Mucke for providing the PDAPP (J9) transgenic mice line, Dr. Jim Patrick for providing the α7nAChRKO mice, and Dr. Edward Koo for performing the capture ELISA for analysis of biochemically extracted Aβ. We also thank Dr. Michael Saganich and Dr Edward Han for their kind input on setting up the electrophysiology experiments and data interpretation; Dr. Lida Becerra for her help with some statistical analysis; Dr. T. K. Booker and Brian Glogowski for proofreading this manuscript; and Vanessa Ferraro, Conny Maron, and Amanda Vlasveld for extensively genotyping our mice colony.

  • Correspondence should be addressed to Dr. Gustavo Dziewczapolski, Molecular Neurobiology Laboratory, The Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, CA 92037. gustavo{at}salk.edu

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Jul 2009621337686
Aug 2009138170206
Sep 200951115108
Oct 20098887104
Nov 2009948483
Dec 2009665356
Total 200910588461243
Jan 201037111103
Feb 2010407577
Mar 2010268354
Apr 2010337676
May 2010326150
Jun 2010216342
Jul 2010233537
Aug 2010364238
Sep 2010205150
Oct 2010305470
Nov 2010274453
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Total 2010343735690
Jan 2011254161
Feb 2011354435
Mar 2011425339
Apr 2011173734
May 2011152821
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Jul 2011221925
Aug 2011241717
Sep 2011202623
Oct 2011263331
Nov 2011193125
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Total 2011289388350
Jan 2012302521
Feb 2012351815
Mar 2012242516
Apr 2012422624
May 2012393236
Jun 2012271917
Jul 2012191515
Aug 2012151718
Sep 201261018
Oct 2012294042
Nov 2012483842
Dec 2012392023
Total 2012353285287
Jan 2013171418
Feb 2013311225
Mar 2013392019
Apr 2013342118
May 2013311731
Jun 2013171437
Jul 2013183634
Aug 2013181818
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Total 2013332251286
Jan 2014181313
Feb 2014262119
Mar 2014452617
Apr 201421138
May 2014522618
Jun 201432185
Jul 201423158
Aug 2014112011
Sep 201441410
Oct 201419811
Nov 201422146
Dec 2014172020
Total 2014290208146
Jan 201525168
Feb 2015252214
Mar 20151786
Apr 201527128
May 201514136
Jun 2015151321
Jul 2015271514
Aug 20151578
Sep 201561410
Oct 201520127
Nov 20151286
Dec 201522179
Total 2015225157117
Jan 2016391014
Feb 2016331413
Mar 2016491723
Apr 201628910
May 20161494
Jun 201624912
Jul 2016291211
Aug 20161346
Sep 2016231511
Oct 2016101816
Nov 2016122910
Dec 201662610
Total 2016280172140
Jan 201711329
Feb 20174127
Mar 201722511
Apr 20173236
May 2017104922
Jun 20171257
Jul 20172166
Aug 20172185
Sep 20170146
Oct 201722316
Nov 20172209
Dec 20174167
Total 201743273111
Jan 20181157
Feb 201852016
Mar 20185207
Apr 2018173310
May 20184378
Jun 20184289
Jul 20182217
Aug 20188169
Sep 201833410
Oct 20182629
Nov 20186529
Dec 20186433
Total 201863381104
Jan 2019420311
Feb 20191263
Mar 201973327
Apr 20194159
May 201951810
Jun 20191185
Jul 2019175
Aug 20192309
Sep 20193647
Oct 20191826
Nov 201921711
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Total 201937532113
Jan 20203172
Feb 2020436
Mar 20206207
Apr 2020344
May 202022420
Jun 20200165
Jul 20207158
Aug 20204118
Sep 20209208
Oct 20209136
Nov 2020133216
Dec 20207284
Total 20206720394
Jan 202152912
Feb 2021123714
Mar 2021163113
Apr 202192218
May 202162110
Jun 20216277
Jul 202172511
Aug 202143010
Sep 20215217
Oct 202162618
Nov 202181916
Dec 20214238
Total 202188311144
Jan 202292826
Feb 2022122319
Mar 202281916
Apr 20224299
Total 2022339970
Total350148413895
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The Journal of Neuroscience: 29 (27)
Journal of Neuroscience
Vol. 29, Issue 27
8 Jul 2009
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Deletion of the α7 Nicotinic Acetylcholine Receptor Gene Improves Cognitive Deficits and Synaptic Pathology in a Mouse Model of Alzheimer's Disease
Gustavo Dziewczapolski, Carolina M. Glogowski, Eliezer Masliah, Stephen F. Heinemann
Journal of Neuroscience 8 July 2009, 29 (27) 8805-8815; DOI: 10.1523/JNEUROSCI.6159-08.2009

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Deletion of the α7 Nicotinic Acetylcholine Receptor Gene Improves Cognitive Deficits and Synaptic Pathology in a Mouse Model of Alzheimer's Disease
Gustavo Dziewczapolski, Carolina M. Glogowski, Eliezer Masliah, Stephen F. Heinemann
Journal of Neuroscience 8 July 2009, 29 (27) 8805-8815; DOI: 10.1523/JNEUROSCI.6159-08.2009
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