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Articles, Behavioral/Systems/Cognitive

Enhanced Visual Motion Perception in Major Depressive Disorder

Julie D. Golomb, Jenika R. B. McDavitt, Barbara M. Ruf, Jason I. Chen, Aybala Saricicek, Kathleen H. Maloney, Jian Hu, Marvin M. Chun and Zubin Bhagwagar
Journal of Neuroscience 15 July 2009, 29 (28) 9072-9077; https://doi.org/10.1523/JNEUROSCI.1003-09.2009
Julie D. Golomb
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Jenika R. B. McDavitt
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Barbara M. Ruf
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Jason I. Chen
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Aybala Saricicek
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Kathleen H. Maloney
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Jian Hu
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Marvin M. Chun
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Zubin Bhagwagar
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Article Information

DOI 
https://doi.org/10.1523/JNEUROSCI.1003-09.2009
PubMed 
19605644
Published By 
Society for Neuroscience
History 
  • Received February 27, 2009
  • Revision received June 1, 2009
  • Accepted June 11, 2009
  • First published July 15, 2009.
  • Version of record published July 15, 2009.
Copyright & Usage 
Copyright © 2009 Society for Neuroscience 0270-6474/09/299072-06$15.00/0

Author Information

  1. Julie D. Golomb1,
  2. Jenika R. B. McDavitt2,
  3. Barbara M. Ruf3,
  4. Jason I. Chen3,
  5. Aybala Saricicek3,
  6. Kathleen H. Maloney3,
  7. Jian Hu3,
  8. Marvin M. Chun1,2, and
  9. Zubin Bhagwagar3
  1. 1Interdepartmental Neuroscience Program and
  2. 2Department of Psychology, Yale University, and
  3. 3Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut 06520
  1. Correspondence should be addressed to either Julie Golomb or Marvin M. Chun, Department of Psychology, Yale University, P.O. Box 208205, New Haven, CT 06520-8205, julie.golomb{at}yale.edu or marvin.chun{at}yale.edu; or Zubin Bhagwagar, Clinical Neuroscience Research Unit, Abraham Ribicoff Research Facilities, Connecticut Mental Health Center, 34 Park Street, New Haven, CT 06519. zubin.bhagwagar{at}yale.edu
  • J. R. B. McDavitt's present address: Department of Psychology, University of Illinois, Urbana-Champaign, Champaign, IL 61820.

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Author contributions

  • J. R. B. McDavitt's present address: Department of Psychology, University of Illinois, Urbana-Champaign, Champaign, IL 61820.

Disclosures

    • Received February 27, 2009.
    • Revision received June 1, 2009.
    • Accepted June 11, 2009.
  • This work was supported by research grants from the National Institutes of Health (Grants R01-EY014193 and P30-EY000785 to M.M.C., K23-MH077914 to Z.B., and F31-MH083374 to J.D.G.), the National Science Foundation (Graduate Research Fellowship to J.D.G.), the National Alliance for Research on Schizophrenia and Depression (Z.B.), and the Clinical and Translational Science Award Grant UL1 RR024139 from the National Center for Research Resources to Yale University (Z.B.). We acknowledge support from the Clinical Neuroscience Research Unit at the Connecticut Mental Health Center and the Connecticut Department of Mental Health and Addictions Services, and we thank A. Leber and N. Turk-Browne for helpful comments and discussion.

  • Correspondence should be addressed to either Julie Golomb or Marvin M. Chun, Department of Psychology, Yale University, P.O. Box 208205, New Haven, CT 06520-8205, julie.golomb{at}yale.edu or marvin.chun{at}yale.edu; or Zubin Bhagwagar, Clinical Neuroscience Research Unit, Abraham Ribicoff Research Facilities, Connecticut Mental Health Center, 34 Park Street, New Haven, CT 06519. zubin.bhagwagar{at}yale.edu

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Total145337751362
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The Journal of Neuroscience: 29 (28)
Journal of Neuroscience
Vol. 29, Issue 28
15 Jul 2009
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Enhanced Visual Motion Perception in Major Depressive Disorder
Julie D. Golomb, Jenika R. B. McDavitt, Barbara M. Ruf, Jason I. Chen, Aybala Saricicek, Kathleen H. Maloney, Jian Hu, Marvin M. Chun, Zubin Bhagwagar
Journal of Neuroscience 15 July 2009, 29 (28) 9072-9077; DOI: 10.1523/JNEUROSCI.1003-09.2009

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Enhanced Visual Motion Perception in Major Depressive Disorder
Julie D. Golomb, Jenika R. B. McDavitt, Barbara M. Ruf, Jason I. Chen, Aybala Saricicek, Kathleen H. Maloney, Jian Hu, Marvin M. Chun, Zubin Bhagwagar
Journal of Neuroscience 15 July 2009, 29 (28) 9072-9077; DOI: 10.1523/JNEUROSCI.1003-09.2009
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  • The role of cortical surround-suppression in this psychophysical effect is disputed
    Craig R Aaen-Stockdale
    Published on: 14 August 2009
  • Published on: (14 August 2009)
    Page navigation anchor for The role of cortical surround-suppression in this psychophysical effect is disputed
    The role of cortical surround-suppression in this psychophysical effect is disputed
    • Craig R Aaen-Stockdale, Postdoctoral Research Assistant

    In this paper, Golomb et al. use a psychophysical technique developed by Tadin et al (2003) to measure surround-suppressive interactions in visual cortex. However, there is actually very little evidence that thresholds obtained with this technique have anything to do with center-surround antagonism. My colleagues and I published data, concurrently with Golomb et al., which suggest that the paradoxical "impairments" in...

    Show More

    In this paper, Golomb et al. use a psychophysical technique developed by Tadin et al (2003) to measure surround-suppressive interactions in visual cortex. However, there is actually very little evidence that thresholds obtained with this technique have anything to do with center-surround antagonism. My colleagues and I published data, concurrently with Golomb et al., which suggest that the paradoxical "impairments" in motion perception in normal subjects (and therefore perceived "improvements" in abnormal populations) are a consequence of how the contrast and size of the stimulus are co-varied (Aaen-Stockdale et al., 2009). We found that motion discrimination thresholds are entirely predictable from the observer's contrast threshold at each stimulus size. These low-level factors can explain the effect reasonably well without any need to invoke center-surround antagonism. It remains to be seen what is causing the difference between normal subjects and recovered depressives, but we suspect that it is not surround suppression. This obviously throws doubt on the speculative connection with degraded GABAergic center-surround mechanisms in the depressed population.

    Aaen-Stockdale, C. R., Thompson, B., Huang, P.-C., & Hess, R. F. (2009). Low-level mechanisms may contribute to paradoxical motion percepts. Journal of Vision, 9(5):9, 1-14, http://journalofvision.org/9/5/9/, doi:10.1167/9.5.9.

    Tadin, D., Lappin, J. S., Gilroy, L. A., & Blake, R. (2003). Perceptual consequences of centre-surround antagonism in visual motion processing. Nature, 424, 312–315.

    Show Less
    Competing Interests: None declared.

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