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Brief Communications

Parkin Protects against LRRK2 G2019S Mutant-Induced Dopaminergic Neurodegeneration in Drosophila

Chee-Hoe Ng, Shaun Z. S. Mok, Cherlyn Koh, Xuezhi Ouyang, Marc L. Fivaz, Eng-King Tan, Valina L. Dawson, Ted M. Dawson, Fengwei Yu and Kah-Leong Lim
Journal of Neuroscience 9 September 2009, 29 (36) 11257-11262; DOI: https://doi.org/10.1523/JNEUROSCI.2375-09.2009
Chee-Hoe Ng
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Shaun Z. S. Mok
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Cherlyn Koh
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Xuezhi Ouyang
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Marc L. Fivaz
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Eng-King Tan
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Valina L. Dawson
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Ted M. Dawson
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Fengwei Yu
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Kah-Leong Lim
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Article Information

DOI 
https://doi.org/10.1523/JNEUROSCI.2375-09.2009
PubMed 
19741132
Published By 
Society for Neuroscience
History 
  • Received May 21, 2009
  • Revision received July 30, 2009
  • Accepted August 3, 2009
  • First published September 9, 2009.
  • Version of record published September 9, 2009.
Copyright & Usage 
Copyright © 2009 Society for Neuroscience 0270-6474/09/2911257-06$15.00/0

Author Information

  1. Chee-Hoe Ng1,
  2. Shaun Z. S. Mok1,
  3. Cherlyn Koh1,
  4. Xuezhi Ouyang2,
  5. Marc L. Fivaz3,
  6. Eng-King Tan1,3,
  7. Valina L. Dawson6,
  8. Ted M. Dawson6,
  9. Fengwei Yu2,4, and
  10. Kah-Leong Lim1,3,5
  1. 1National Neuroscience Institute, Singapore 308433,
  2. 2Temasek Life Sciences Laboratory, Singapore 117604,
  3. 3Duke–NUS Graduate Medical School, Singapore 169857,
  4. Departments of 4Biological Sciences and
  5. 5Physiology, National University of Singapore, Singapore 119077, and
  6. 6Neuroregeneration and Stem Cell Programs, Institute for Cell Engineering, Department of Neurology, Solomon H. Snyder Department of Neuroscience, and Department of Physiology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205
  1. Correspondence should be addressed to Dr. Kah-Leong Lim, Neurodegeneration Research Laboratory, National Neuroscience Institute, 11 Jalan Tan Tock Seng, Singapore 308433. Kah_Leong_Lim{at}nni.com.sg or kahleong.lim{at}duke-nus.edu.sg
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Author contributions

Disclosures

    • Received May 21, 2009.
    • Revision received July 30, 2009.
    • Accepted August 3, 2009.
  • This work was supported by grants from the Singhealth Foundation, Duke–NUS Graduate Medical School and Singapore Millennium Foundation. C.-H.N. is supported by the Singapore National Medical Research Council and Singapore Millennium Foundation. F.Y. is supported by Temasek Life Sciences Laboratory. T.M.D. and V.L.D. are supported by National Institutes of Health–National Institute of Neurological Disorders and Stroke Grant P50 NS38377. T.M.D. is the Leonard and Madlyn Abramson Professor in Neurodegenerative Diseases. We thank Henry Zhu Liqun and Dr. Eva Andres-Mateos for their assistance with HPLC measurement of dopamine.

  • Correspondence should be addressed to Dr. Kah-Leong Lim, Neurodegeneration Research Laboratory, National Neuroscience Institute, 11 Jalan Tan Tock Seng, Singapore 308433. Kah_Leong_Lim{at}nni.com.sg or kahleong.lim{at}duke-nus.edu.sg

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Article usage: September 2009 to June 2022

AbstractFullPdf
Sep 2009417260429
Oct 200985121160
Nov 2009449182
Dec 2009486057
Total 2009594532728
Jan 2010275941
Feb 2010398174
Mar 2010205562
Apr 2010155958
May 2010153531
Jun 201054221
Jul 201083529
Aug 2010193333
Sep 2010183442
Oct 2010193443
Nov 2010123823
Dec 2010123325
Total 2010209538482
Jan 2011164134
Feb 2011163136
Mar 2011232827
Apr 2011233224
May 2011192418
Jun 2011182225
Jul 2011162723
Aug 2011342336
Sep 2011302022
Oct 2011303631
Nov 2011262437
Dec 2011281622
Total 2011279324335
Jan 2012191617
Feb 2012392424
Mar 2012233228
Apr 2012372325
May 2012232831
Jun 2012243023
Jul 2012312122
Aug 2012352529
Sep 2012151421
Oct 2012561620
Nov 2012402320
Dec 2012452423
Total 2012387276283
Jan 2013322026
Feb 2013333219
Mar 2013203121
Apr 20132598
May 2013131712
Jun 2013271313
Jul 2013123518
Aug 2013193215
Sep 2013523215
Oct 2013293227
Nov 2013282720
Dec 201314157
Total 2013304295201
Jan 2014192514
Feb 2014232616
Mar 201418198
Apr 201421269
May 2014181414
Jun 2014252013
Jul 2014452613
Aug 2014172220
Sep 201427224
Oct 201427378
Nov 2014193215
Dec 2014261514
Total 2014285284148
Jan 2015182119
Feb 201519179
Mar 2015461018
Apr 2015212213
May 201513128
Jun 2015161814
Jul 2015883
Aug 20151695
Sep 201523128
Oct 2015191310
Nov 201512147
Dec 20152158
Total 2015232161122
Jan 2016311422
Feb 2016202511
Mar 2016311418
Apr 2016201718
May 2016211111
Jun 2016231314
Jul 2016241215
Aug 201612610
Sep 201612410
Oct 20167123
Nov 20164115
Dec 20162155
Total 2016207154142
Jan 201742812
Feb 2017191
Mar 201752426
Apr 201723218
May 20174328
Jun 20174238
Jul 20174135
Aug 20174162
Sep 20175208
Oct 201731411
Nov 20177186
Dec 20173105
Total 201746239110
Jan 20189208
Feb 201852111
Mar 201810193
Apr 20182156
May 201882711
Jun 20186258
Jul 20181174
Aug 20181205
Sep 20185227
Oct 20188188
Nov 20188225
Dec 20182164
Total 20186524280
Jan 201972313
Feb 20195198
Mar 201992613
Apr 20195169
May 201981310
Jun 20195199
Jul 201962512
Aug 201941618
Sep 20191124
Oct 20198155
Nov 20195278
Dec 20194105
Total 201967221114
Jan 2020111911
Feb 202032212
Mar 2020483
Apr 2020154619
May 202071814
Jun 20204106
Jul 20203117
Aug 20204105
Sep 20206183
Oct 202081917
Nov 2020122811
Dec 202093318
Total 202086242126
Jan 202132711
Feb 20212223
Mar 202165324
Apr 202172614
May 20217264
Jun 202183211
Jul 20215209
Aug 20213216
Sep 202152010
Oct 202173025
Nov 202161921
Dec 20215187
Total 202164314145
Jan 202242916
Feb 202213249
Mar 2022152922
Apr 20226258
May 202282814
Jun 202232115
Total 20224915684
Total287439783100
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The Journal of Neuroscience: 29 (36)
Journal of Neuroscience
Vol. 29, Issue 36
9 Sep 2009
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Parkin Protects against LRRK2 G2019S Mutant-Induced Dopaminergic Neurodegeneration in Drosophila
Chee-Hoe Ng, Shaun Z. S. Mok, Cherlyn Koh, Xuezhi Ouyang, Marc L. Fivaz, Eng-King Tan, Valina L. Dawson, Ted M. Dawson, Fengwei Yu, Kah-Leong Lim
Journal of Neuroscience 9 September 2009, 29 (36) 11257-11262; DOI: 10.1523/JNEUROSCI.2375-09.2009

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Parkin Protects against LRRK2 G2019S Mutant-Induced Dopaminergic Neurodegeneration in Drosophila
Chee-Hoe Ng, Shaun Z. S. Mok, Cherlyn Koh, Xuezhi Ouyang, Marc L. Fivaz, Eng-King Tan, Valina L. Dawson, Ted M. Dawson, Fengwei Yu, Kah-Leong Lim
Journal of Neuroscience 9 September 2009, 29 (36) 11257-11262; DOI: 10.1523/JNEUROSCI.2375-09.2009
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