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Brief Communications

The Structural Integrity of an Amygdala–Prefrontal Pathway Predicts Trait Anxiety

M. Justin Kim and Paul J. Whalen
Journal of Neuroscience 16 September 2009, 29 (37) 11614-11618; https://doi.org/10.1523/JNEUROSCI.2335-09.2009
M. Justin Kim
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Paul J. Whalen
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    Figure 1.

    Amygdala–vmPFC pathway identified based on variability in functional activation of the amygdala. Statistical map showing FA voxels that are positively correlated with amygdala reactivity to fearful versus neutral faces (p < 0.05, corrected) in sagittal and coronal slices. The color bars indicate p values.

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    Figure 2.

    Correlation between the structural integrity of an amygdala–vmPFC pathway and trait anxiety. FA values of an amygdala–vmPFC pathway (r = −0.515; p < 0.05), shown in Figure 1, were negatively correlated with trait anxiety.

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    Table 1.

    Nearest gray matter brain regions of voxels within an amygdala–vmPFC pathway that was identified based on the variability in functional activation of the amygdala

    Nearest gray matter brain regionsCluster size (mm3)MNI coordinatest
    xyz
    L orbitofrontal cortex5321−1725−204.51
    L anterior cingulate cortex−816−103.48
    L subcallosal gyrus−248−173.83
    L putamen−183−82.70
    L amygdala−273−112.14
    R putamen1426256−123.69
    R caudate105−42.62
    R pallidum182−72.40
    • L, Left; R, right.

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The Journal of Neuroscience: 29 (37)
Journal of Neuroscience
Vol. 29, Issue 37
16 Sep 2009
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The Structural Integrity of an Amygdala–Prefrontal Pathway Predicts Trait Anxiety
M. Justin Kim, Paul J. Whalen
Journal of Neuroscience 16 September 2009, 29 (37) 11614-11618; DOI: 10.1523/JNEUROSCI.2335-09.2009

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The Structural Integrity of an Amygdala–Prefrontal Pathway Predicts Trait Anxiety
M. Justin Kim, Paul J. Whalen
Journal of Neuroscience 16 September 2009, 29 (37) 11614-11618; DOI: 10.1523/JNEUROSCI.2335-09.2009
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