Inhibition of Monoamine Oxidases Desensitizes 5-HT_1A Autoreceptors and Allows Nicotine to Induce a Neurochemical and Behavioral Sensitization

This work was supported by Institut National de la Santé et de la Recherche Médicale and Université Pierre et Marie Curie, and C.L. and L.S. have received a fellowship from the Mission Interministérielle de Lutte Contre la Drogue et la Toxicomanie and Ministère de la Recherche et de la Technologie, respectively. We thank Drs. Joëlle Adrien, Edith Doucet, Laurence Lanfumey, and Michel Hamon for the 5-HT_1A and 5-HTT antibodies, for their advice in the determination of 5-HT_1A receptor desensitization, and for the gift of mice depleted in 5-HT_1A receptors. We thank Drs. Véronique Béréziat, Sakina Mhaouty-Kodja, and Sébastien Parnaudeau for their precious advice on protein membrane fractioning and Western blotting. We thank Patricia Cougnot and Robert Poulhe for skillful technical assistance.