Oxidative stress | | |
Ferritin heavy polypeptide 1 | 6.68* | Protective during oxidative stress (Chiba et al., 2007). |
Thioredoxin reductase 1 | 2.64# | Protective during oxidative stress (Xia et al., 2003); upregulated in DRG at 14 d in a model of HIV neuropathy (Maratou et al., 2009). |
Prothymosin α | 2.56* | Regulates apoptosis and oxidative stress (Karapetian et al., 2005; Fujita and Ueda, 2007); upregulated in DRG 14 d after SNTa(Maratou et al., 2009). |
Membrane–cytoskeletal signaling | | |
Myristoylated alanine-rich C-kinase substrate-like 1, MARCKSL1 | 2.12# | Protein kinase C (PKC) substrate, which binds actin, calmodulin, and acidic phospholipids. |
Brain abundant membrane attached signal protein 1 (BASP1/CAP-23) | 2.28## | PKC substrate, which binds actin, calmodulin, and acidic phospholipids; upregulated in DRG 3, 6, and 14 d after sciatic nerve crush (Mason et al., 2002). |
Gravin/A kinase anchor protein (AKAP12) | 2.68# | Scaffold protein that interacts with PKA, PKC, and actin; expressed in unmyelinated sensory neurons (Irmen et al., 2008). |
Tropomyosin 4 | 2.17### | Neuronal tropomyosin found in growth cones and presynaptic terminals (Had et al., 1994); upregulated 7 d after SNL (Komori et al., 2007). |
Thymosin β4 | 2.03### | Actin-sequestering protein; promotes wound healing and repair after hypoxia (Goldstein et al., 2005); upregulated in DRG 14 d after SNT (Maratou et al., 2009). |
Transcription regulation | | |
APEX nuclease | 3.95# | DNA repair and regulation of transcription factors (Vasko et al., 2005; Qu et al., 2007). |
Y box binding protein 1 (YBX1) | 3.27# | Transcription factor and translation regulator (Kohno et al., 2003); upregulated in DRG 14 d after SNT (Maratou et al., 2009). |
Neuropeptide signaling | | |
CGRP precursor | 5.19* | CGRP is expressed in nociceptive sensory neurons. Complex regulation in nerve injury, see Discussion. |
Neurosecretory protein VGF | 45.35# | Putative precursor of signaling peptides; upregulated 3 d after sciatic nerve axotomy and 14 d after SNL (Costigan et al., 2002;Wang et al., 2002; Valder et al., 2003). |
Other | | |
Diazepam binding inhibitor (DBI) | 2.33* | Stimulation of steroid synthesis. DBI expressed in satellite cells, expression not altered 3 d after sciatic nerve transection (Karchewski et al., 2004); upregulated in DRG 14 d after SNT (Maratou et al., 2009). |
Proteasome P20 subunit (PSMB7) | 2.13# | Protein degradation. Proteasome activity affects nerve injury induced hypersensitivity (Moss et al., 2003; Ossipov et al., 2007). |
α-Galactosidase | 2.21## | Glycolipid and glycoprotein degradation. Mutations associated with Fabry's disease. Downregulated in DRG 14 d after SNT (Maratou et al., 2009). |
Palmytoyl-protein thioesterase 1 | 2.38# | Lysosomal enzyme involved in degradation of lipoproteins. Mutations associated with neurodegeneration (Gardiner, 2000). |
Acetyl-coenzyme A acetyltransferase 2 | 2.68## | Peroxysomal enzyme involved in fatty acid metabolism. |
Cell cycle exit and neuronaldifferentiation 1 (CEND1) | 2.87## | Function described by Politis et al. (2007). |
LSM3 homolog, U6 small nuclear RNA associated | 2.12# | Upregulated in DRG 14 d after SNT (Maratou et al., 2009). Function described by Beggs (2005). |