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Articles, Cellular/Molecular

Polar Residues in the Second Transmembrane Domain of the Rat P2X2 Receptor That Affect Spontaneous Gating, Unitary Conductance, and Rectification

Lishuang Cao, Helen E. Broomhead, Mark T. Young and R. Alan North
Journal of Neuroscience 11 November 2009, 29 (45) 14257-14264; https://doi.org/10.1523/JNEUROSCI.4403-09.2009
Lishuang Cao
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Helen E. Broomhead
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Mark T. Young
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R. Alan North
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Article Information

DOI 
https://doi.org/10.1523/JNEUROSCI.4403-09.2009
PubMed 
19906973
Published By 
Society for Neuroscience
History 
  • Received September 6, 2009
  • Revision received September 29, 2009
  • Accepted October 5, 2009
  • First published November 11, 2009.
  • Version of record published November 11, 2009.
Copyright & Usage 
Copyright © 2009 Society for Neuroscience 0270-6474/09/2914257-08$15.00/0

Author Information

  1. Lishuang Cao,
  2. Helen E. Broomhead,
  3. Mark T. Young, and
  4. R. Alan North
  1. Faculty of Medical and Human Sciences, and Faculty of Life Sciences, University of Manchester, Manchester M13 9PL, United Kingdom
  1. Correspondence should be addressed to R. Alan North, Michael Smith Building, University of Manchester, Oxford Road, Manchester M13 9PL, UK. r.a.north{at}manchester.ac.uk
  • L. Cao's present address: Pain Research Unit, Pfizer Global Research and Development, Ramsgate Road, Sandwich, Kent CT13 9NJ, UK.

  • H. E. Broomhead's present address: Department of Biochemistry, University of Cambridge, Sanger Building, 80 Tennis Court Road, Cambridge CB2 1GA, UK.

  • M. T. Young's present address: School of Biosciences, Cardiff University, Cardiff CF10 3AX, UK.

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Author contributions

  • L. Cao's present address: Pain Research Unit, Pfizer Global Research and Development, Ramsgate Road, Sandwich, Kent CT13 9NJ, UK.

  • H. E. Broomhead's present address: Department of Biochemistry, University of Cambridge, Sanger Building, 80 Tennis Court Road, Cambridge CB2 1GA, UK.

  • M. T. Young's present address: School of Biosciences, Cardiff University, Cardiff CF10 3AX, UK.

Disclosures

    • Received September 6, 2009.
    • Revision received September 29, 2009.
    • Accepted October 5, 2009.
  • This work was supported by The Wellcome Trust. We thank Kyriaki Dossi and Lara Bragg for tissue culture. We are grateful to Fred Sachs of State University of New York for advice on single-channel methodology and interpretation.

  • Correspondence should be addressed to R. Alan North, Michael Smith Building, University of Manchester, Oxford Road, Manchester M13 9PL, UK. r.a.north{at}manchester.ac.uk

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The Journal of Neuroscience: 29 (45)
Journal of Neuroscience
Vol. 29, Issue 45
11 Nov 2009
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Polar Residues in the Second Transmembrane Domain of the Rat P2X2 Receptor That Affect Spontaneous Gating, Unitary Conductance, and Rectification
Lishuang Cao, Helen E. Broomhead, Mark T. Young, R. Alan North
Journal of Neuroscience 11 November 2009, 29 (45) 14257-14264; DOI: 10.1523/JNEUROSCI.4403-09.2009

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Polar Residues in the Second Transmembrane Domain of the Rat P2X2 Receptor That Affect Spontaneous Gating, Unitary Conductance, and Rectification
Lishuang Cao, Helen E. Broomhead, Mark T. Young, R. Alan North
Journal of Neuroscience 11 November 2009, 29 (45) 14257-14264; DOI: 10.1523/JNEUROSCI.4403-09.2009
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