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Brief Communications

Why Sex Matters: Brain Size Independent Differences in Gray Matter Distributions between Men and Women

Eileen Luders, Christian Gaser, Katherine L. Narr and Arthur W. Toga
Journal of Neuroscience 11 November 2009, 29 (45) 14265-14270; https://doi.org/10.1523/JNEUROSCI.2261-09.2009
Eileen Luders
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Christian Gaser
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Katherine L. Narr
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Arthur W. Toga
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    Figure 1.

    Sex differences in regional GM (main effect and subsamples). Displayed are maximum intensity projections superimposed onto the SPM standard glass brain template (sagittal and coronal view). a illustrates the main effect of sex (bidirectional). Statistical outcomes are corrected for multiple comparisons using FDR at p = 0.05. Shown are clusters exceeding a spatial extent threshold of 1000 voxels, which corresponds to the expected numbers of voxels per cluster. b–e illustrate the outcomes of the subsequent post hoc tests, where women have larger regional GM volumes than men (women > men). The illustrated spatial profiles are significant at p = 0.001 (uncorrected) without applying cluster extent thresholds.

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    Figure 2.

    Sex differences in regional GM (matched sample). Displayed are section views of the single subject SPM standard brain. The clusters indicate brain regions where the matched women had significantly larger GM volumes than the matched men. The color intensity represents t-statistic values at the voxel level. Statistical outcomes are corrected for multiple comparisons using FDR at p = 0.05. Shown are clusters exceeding a spatial extent threshold of 1000 voxels and the respective cluster-specific local maxima (see crosshairs), including their MNI coordinates. The results are presented in neurological convention (right is right).

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    Table 1.

    Age and total brain volume (TBV)

    Matched sample (n = 48)Extreme sample (n = 48)
    Men (n = 24)Women (n = 24)Men (n = 24)Women (n = 24)
    Age42.96 ± 12.3143.88 ± 14.7439.33 ± 14.7945.75 ± 13.64
    TBV1406.57 ± 101.691406.62 ± 101.411623.74 ± 68.941221.58 ± 62.99
    • Age (mean ± SD) is shown in years; TBV (mean ± standard deviation) is shown in milliliters. Matched men and matched women do not differ with respect to TBV. Extreme men consist of men with the largest TBVs; extreme women consist of women with the smallest TBVs.

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The Journal of Neuroscience: 29 (45)
Journal of Neuroscience
Vol. 29, Issue 45
11 Nov 2009
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Why Sex Matters: Brain Size Independent Differences in Gray Matter Distributions between Men and Women
Eileen Luders, Christian Gaser, Katherine L. Narr, Arthur W. Toga
Journal of Neuroscience 11 November 2009, 29 (45) 14265-14270; DOI: 10.1523/JNEUROSCI.2261-09.2009

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Why Sex Matters: Brain Size Independent Differences in Gray Matter Distributions between Men and Women
Eileen Luders, Christian Gaser, Katherine L. Narr, Arthur W. Toga
Journal of Neuroscience 11 November 2009, 29 (45) 14265-14270; DOI: 10.1523/JNEUROSCI.2261-09.2009
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