Cover legend: Confocal view of a mouse neuromuscular junction, showing a preterminal axon and its terminal arbor in green, Schwann cells in blue, and postsynaptic clusters of nicotinic acetylcholine receptors (nAChRs) in the muscle fiber in red. Normal maintenance of this tripartite organization requires subtype-specific muscarinic AChR (mAChR) signaling. For more information, see the article by Wright et al. in this issue (pages 14942–14955).