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Brief Communications

Cannabidiol, a Nonpsychotropic Component of Cannabis, Inhibits Cue-Induced Heroin Seeking and Normalizes Discrete Mesolimbic Neuronal Disturbances

Yanhua Ren, John Whittard, Alejandro Higuera-Matas, Claudia V. Morris and Yasmin L. Hurd
Journal of Neuroscience 25 November 2009, 29 (47) 14764-14769; https://doi.org/10.1523/JNEUROSCI.4291-09.2009
Yanhua Ren
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John Whittard
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Alejandro Higuera-Matas
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Claudia V. Morris
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Yasmin L. Hurd
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Abstract

There remains debate regarding the impact of cannabis on neuropsychiatric disorders. Here, we examined the effects of cannabidiol (CBD), a nonpsychoactive constituent of cannabis, on heroin self-administration and drug-seeking behavior using an experimental rat model. CBD (5–20 mg/kg) did not alter stable intake of heroin self-administration, extinction behavior, or drug seeking induced by a heroin prime injection. Instead, it specifically attenuated heroin-seeking behavior reinstated by exposure to a conditioned stimulus cue. CBD had a protracted effect with significance evident after 24 h and even 2 weeks after administration. The behavioral effects were paralleled by neurobiological alterations in the glutamatergic and endocannabinoid systems. Discrete disturbances of AMPA GluR1 and cannabinoid type-1 receptor expression observed in the nucleus accumbens associated with stimulus cue-induced heroin seeking were normalized by CBD treatment. The findings highlight the unique contributions of distinct cannabis constituents to addiction vulnerability and suggest that CBD may be a potential treatment for heroin craving and relapse.

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The Journal of Neuroscience: 29 (47)
Journal of Neuroscience
Vol. 29, Issue 47
25 Nov 2009
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Cannabidiol, a Nonpsychotropic Component of Cannabis, Inhibits Cue-Induced Heroin Seeking and Normalizes Discrete Mesolimbic Neuronal Disturbances
Yanhua Ren, John Whittard, Alejandro Higuera-Matas, Claudia V. Morris, Yasmin L. Hurd
Journal of Neuroscience 25 November 2009, 29 (47) 14764-14769; DOI: 10.1523/JNEUROSCI.4291-09.2009

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Cannabidiol, a Nonpsychotropic Component of Cannabis, Inhibits Cue-Induced Heroin Seeking and Normalizes Discrete Mesolimbic Neuronal Disturbances
Yanhua Ren, John Whittard, Alejandro Higuera-Matas, Claudia V. Morris, Yasmin L. Hurd
Journal of Neuroscience 25 November 2009, 29 (47) 14764-14769; DOI: 10.1523/JNEUROSCI.4291-09.2009
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