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Brief Communications

Fornix Microstructure Correlates with Recollection But Not Familiarity Memory

Sarah R. Rudebeck, Jan Scholz, Rebecca Millington, Gustavo Rohenkohl, Heidi Johansen-Berg and Andy C. H. Lee
Journal of Neuroscience 25 November 2009, 29 (47) 14987-14992; DOI: https://doi.org/10.1523/JNEUROSCI.4707-09.2009
Sarah R. Rudebeck
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Jan Scholz
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Rebecca Millington
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Gustavo Rohenkohl
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Heidi Johansen-Berg
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Andy C. H. Lee
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    Figure 1.

    Average ROC curves for the scene (dashed line/squares) and object (solid line/triangles) recognition tasks.

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    Figure 2.

    A, Positive correlation between FA and recollection in the left fornix tail as identified by TBSS (max t = 5.44). The statistical image was thresholded at p = 0.05 (uncorrected) for display purposes and overlaid on the MNI template and white matter skeleton (green voxels) of all participants. At the max t-statistic voxel, there was a significant correlation between FA and scene (r = 0.75) and object (r = 0.54) recollection (B) but not between FA and scene or object familiarity (both r < 0.1) (C). Extracting mean FA from the fornix tail bilaterally also revealed a significant correlation between FA and scene recollection (r = 0.43) (with a trend toward significance for object recollection; r = 0.38) (D) but not between FA and scene or object familiarity (both r < 0.3) (E).

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    Table 1.

    Behavioral performance across all tasks

    TaskMeasureMeanSDRange
    Scene ROCro0.370.160.10 to 0.72
    d′0.650.40−0.04 to 1.49
    z-ROC slope0.720.120.43 to 0.98
    Da1.170.460.56 to 2.18
    Object ROCro0.420.180.12 to 0.72
    d′0.790.51−0.51 to 1.63
    z-ROC slope0.840.190.51 to 1.15
    Da1.340.390.74 to 2.55
    Color oddityProportion correct0.780.100.60 to 0.94
    Motor attentionNeutral response times/ms809512556204 to 11,536
    Valid response times/ms743112795111 to 9720
    Invalid response times/ms839513576173 to 11,166

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The Journal of Neuroscience: 29 (47)
Journal of Neuroscience
Vol. 29, Issue 47
25 Nov 2009
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Fornix Microstructure Correlates with Recollection But Not Familiarity Memory
Sarah R. Rudebeck, Jan Scholz, Rebecca Millington, Gustavo Rohenkohl, Heidi Johansen-Berg, Andy C. H. Lee
Journal of Neuroscience 25 November 2009, 29 (47) 14987-14992; DOI: 10.1523/JNEUROSCI.4707-09.2009

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Fornix Microstructure Correlates with Recollection But Not Familiarity Memory
Sarah R. Rudebeck, Jan Scholz, Rebecca Millington, Gustavo Rohenkohl, Heidi Johansen-Berg, Andy C. H. Lee
Journal of Neuroscience 25 November 2009, 29 (47) 14987-14992; DOI: 10.1523/JNEUROSCI.4707-09.2009
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