Functional Contribution of Adult-Generated Olfactory Bulb Interneurons: Odor Discrimination versus Odor Memory

Article Figures & Data

Table 1.

Impairment in olfactory-associated behavior after reduction of adult OB neurogenesis

Study	Method of reducing OB neurogenesis	Impact on immatureadult-generated neurons	Impact on mature adult-generatedneurons	Odordiscrimination	Odor memory
Gheusi et al., 2000	NCAM^−/−	Migration in RMS: impaired	GCL width: 35% reduction	Impaired	Impaired short-term(80–100 min)
Enwere et al., 2004	Aging, Lifr^+/−, TGFα^wa1/wa1	BrdU+/calretinin+ cells (4 wkpostinjection): 59% reductionin GL in aged mice	BrdU+/GABA+ cells (4 wk postinjection):41% reduction in GL, 55% reductionin GCL in aged mice	Impaired
Bath et al., 2008	BDNF^+/−, TrkB^+/−, BDNF^Met/Met	Proliferation: no change	BrdU+ cells in GCL (4 wk postinjection):30% reduction	Impaired
Imayoshi et al., 2008	Nestin-CRE-ER^T2 × NSE-DTA	DCX+ cells in RMS: reduced	NeuN+ cells in GCL: 10% reduction	No deficit	No deficit
Lazarini et al., 2009	Focal SVZ irradiation	DCX+ cells in GL and GCL:70% reduction		No deficit	Impaired long-term(30 d)
Breton-Provencheret al., 2009	LV AraC infusion	DCX+ cells in GCL:75% reduction	NeuN+ cells in GCL: no change	No deficit	Impaired short-term(60–120 min)

BrdU, Bromodeoxyuridine; CRE, cAMP response element; GCL, granule cell layer; GL, glomerular layer; LV, lateral ventricle; RMS, rostral migratory stream; SVZ, subventricular zone.