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Articles, Behavioral/Systems/Cognitive

Vasopressin Modulates Medial Prefrontal Cortex–Amygdala Circuitry during Emotion Processing in Humans

Caroline F. Zink, Jason L. Stein, Lucas Kempf, Shabnam Hakimi and Andreas Meyer-Lindenberg
Journal of Neuroscience 19 May 2010, 30 (20) 7017-7022; DOI: https://doi.org/10.1523/JNEUROSCI.4899-09.2010
Caroline F. Zink
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Jason L. Stein
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Lucas Kempf
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Shabnam Hakimi
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Andreas Meyer-Lindenberg
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Abstract

The neuropeptide vasopressin is a modulator of mammalian social behavior and emotion, particularly fear, aggression, and anxiety. In humans, the neural circuitry underlying behavioral effects of vasopressin is unknown. Using a double-blind crossover administration of 40 IU of vasopressin or placebo and functional MRI during processing of facial emotions in healthy male volunteers, we show that vasopressin specifically reduces differential activation in the subgenual cingulate cortex. Structural equation modeling of a previously evaluated circuit between amygdala, subgenual cingulate, and supragenual cingulate revealed altered effective connectivity between subgenual and supragenual cingulate under vasopressin. Our data demonstrate an impact of vasopressin on activity and connectivity in the cortical component of a medial prefrontal cortex–amygdala circuit implicated in emotional regulation, providing the first data on the neural basis for the effects of vasopressin on social behavior in humans with potential therapeutic significance for mood and anxiety disorders.

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The Journal of Neuroscience: 30 (20)
Journal of Neuroscience
Vol. 30, Issue 20
19 May 2010
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Vasopressin Modulates Medial Prefrontal Cortex–Amygdala Circuitry during Emotion Processing in Humans
Caroline F. Zink, Jason L. Stein, Lucas Kempf, Shabnam Hakimi, Andreas Meyer-Lindenberg
Journal of Neuroscience 19 May 2010, 30 (20) 7017-7022; DOI: 10.1523/JNEUROSCI.4899-09.2010

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Vasopressin Modulates Medial Prefrontal Cortex–Amygdala Circuitry during Emotion Processing in Humans
Caroline F. Zink, Jason L. Stein, Lucas Kempf, Shabnam Hakimi, Andreas Meyer-Lindenberg
Journal of Neuroscience 19 May 2010, 30 (20) 7017-7022; DOI: 10.1523/JNEUROSCI.4899-09.2010
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