Article Figures & Data
Figures
- Figure 1.
A, B, Significant changes in the amygdala and mPFC BOLD responses during face-matching blocks relative to form-matching blocks after administration of placebo (A) and vasopressin (B). In both the placebo and vasopressin conditions, bilateral amygdala activity was significantly increased during face matching (left panels; activation maps overlaid on coronal sections of a structural template MRI, y = −6). mPFC (subgenual and supragenual cingulate cortices) activity was significantly decreased during face matching after placebo but not after vasopressin administration (right panels; activation maps overlaid on sagittal sections of a structural template MRI, x = 6). Colorbars represent t values. Statistical significance was thresholded at p < 0.05, corrected for multiple comparisons within the amygdala–mPFC regions of interest.
- Figure 2.
Significantly greater subgenual cingulate cortex activation after vasopressin administration compared with placebo during face-matching blocks relative to form-matching blocks. The activation map of the subgenual cingulate is overlaid on a sagittal section of a structural template MRI (x = 3). The colorbar represents t values.
Tables
- Table 1.
Significant BOLD signal changes during face matching compared to forms matching after placebo or vasopressin administration
Brain region Contrast direction Peak MNI coordinates Voxels in cluster Peak t value x y z Placebo Right amygdala Faces > Forms 18 −6 −24 37 6.91 Left amygdala Faces > Forms −21 −6 −24 14 4.16 Supragenual cingulate Forms > Faces 6 36 30 335 5.27 Including subgenual cingulate Forms > Faces −6 39 −9 4.37 Vasopressin Left amygdala Faces > Forms −18 −6 −24 34 5.55 Right amygdala Faces > Forms 21 −6 −24 50 5.29 Vasopressin > Placebo Subgenual cingulate Faces > Forms 3 39 −9 25 4.50 Placebo > Vasopressin No significant activations -
Significance was measured at p < 0.05, FDR-corrected for multiple comparisons within the mPFC–amygdala region of interest.
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Supplemental Data
Files in this Data Supplement:
- supplemental material - Supplemental Material
