Cover legend: Pseudocolored maximal projection overlay of several confocal images of cultured mouse hippocampal neurons fluorescently labeled with antibodies against microtubule-associated protein (MAP2) (green) and against synapsins (yellow). These cultures have been used to uncover progressive degeneration of GABAergic synapses in knock-out mice lacking cysteine string protein-α. For more information, see the article by García-Junco-Clemente et al. in this issue (pages 7377–7391).