Cover legend: Pentameric modeling of the human α1β glycine receptor (GlyR), viewed from extracellular perspective, showing considerable disruption of Cl^- pore architecture in the Y128C hyperekplexia mutant channel. α1 subunits are in green (Y128C mutant) and β subunits in blue. The mutated residue, C128, is shown in magenta and sections 142–145 and 170–173, which adopt altered α conformation, in red. See the article by Chung et al. in this issue (pages 9612–9620).