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Featured ArticleArticles, Development/Plasticity/Repair

Teashirt 3 Regulates Development of Neurons Involved in Both Respiratory Rhythm and Airflow Control

Xavier Caubit, Muriel Thoby-Brisson, Nicolas Voituron, Pierre Filippi, Michelle Bévengut, Hervé Faralli, Sébastien Zanella, Gilles Fortin, Gérard Hilaire and Laurent Fasano
Journal of Neuroscience 14 July 2010, 30 (28) 9465-9476; DOI: https://doi.org/10.1523/JNEUROSCI.1765-10.2010
Xavier Caubit
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Muriel Thoby-Brisson
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Nicolas Voituron
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Pierre Filippi
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Michelle Bévengut
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Hervé Faralli
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Sébastien Zanella
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Gilles Fortin
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Gérard Hilaire
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Laurent Fasano
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Abstract

Neonatal breathing in mammals involves multiple neuronal circuits, but its genetic basis remains unclear. Mice deficient for the zinc finger protein Teashirt 3 (TSHZ3) fail to breathe and die at birth. Tshz3 is expressed in multiple areas of the brainstem involved in respiration, including the pre-Bötzinger complex (preBötC), the embryonic parafacial respiratory group (e-pF), and cranial motoneurons that control the upper airways. Tshz3 inactivation led to pronounced cell death of motoneurons in the nucleus ambiguus and induced strong alterations of rhythmogenesis in the e-pF oscillator. In contrast, the preBötC oscillator appeared to be unaffected. These deficits result in impaired upper airway function, abnormal central respiratory rhythm generation, and altered responses to pH changes. Thus, a single gene, Tshz3, controls the development of diverse components of the circuitry required for breathing.

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The Journal of Neuroscience: 30 (28)
Journal of Neuroscience
Vol. 30, Issue 28
14 Jul 2010
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Teashirt 3 Regulates Development of Neurons Involved in Both Respiratory Rhythm and Airflow Control
Xavier Caubit, Muriel Thoby-Brisson, Nicolas Voituron, Pierre Filippi, Michelle Bévengut, Hervé Faralli, Sébastien Zanella, Gilles Fortin, Gérard Hilaire, Laurent Fasano
Journal of Neuroscience 14 July 2010, 30 (28) 9465-9476; DOI: 10.1523/JNEUROSCI.1765-10.2010

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Teashirt 3 Regulates Development of Neurons Involved in Both Respiratory Rhythm and Airflow Control
Xavier Caubit, Muriel Thoby-Brisson, Nicolas Voituron, Pierre Filippi, Michelle Bévengut, Hervé Faralli, Sébastien Zanella, Gilles Fortin, Gérard Hilaire, Laurent Fasano
Journal of Neuroscience 14 July 2010, 30 (28) 9465-9476; DOI: 10.1523/JNEUROSCI.1765-10.2010
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