Article Information
- Received January 4, 2010
- Revision received April 26, 2010
- Accepted May 27, 2010
- First published July 21, 2010.
- Version of record published July 21, 2010.
Author Information
- Shaday Michán 1 , 3 ,*,
- Ying Li 4 , 5 ,*,
- Maggie Meng-Hsiu Chou 4 ,
- Edoardo Parrella 5 ,
- Huanying Ge 6 ,
- Jeffrey M. Long 7 ,
- Joanne S. Allard 7 ,
- Kaitlyn Lewis 7 ,
- Marshall Miller 7 ,
- Wei Xu 4 ,
- Ronald F. Mervis 8 , 9 ,
- Jing Chen 2 ,
- Karen I. Guerin 2 ,
- Lois E. H. Smith 2 ,
- Michael W. McBurney 10 ,
- David A. Sinclair 1 ,
- Michel Baudry 4 ,
- Rafael de Cabo 7 , and
- Valter D. Longo 4 , 5
- 1Paul F. Glenn Laboratories, Department of Pathology, Harvard Medical School and
- 2Department of Ophthalmology, Children's Hospital, Harvard Medical School, Boston, Massachusetts 02115,
- 3Instituto de Geriatría, Institutos Nacionales de Salud, 04510 México D.F., México,
- 4Neuroscience Program,
- 5Andrus Gerontology Center and Department of Biological Sciences, and
- 6Molecular and Computational Biology, Department of Biology Sciences, University of Southern California, Los Angeles, California 90089,
- 7Laboratory of Experimental Gerontology, National Institute on Aging, National Institutes of Health, Baltimore, Maryland 21224,
- 8Center of Excellence in Aging and Brain Repair, Department of Neurosurgery and Brain Repair, University of South Florida College of Medicine, Tampa, Florida 33612,
- 9NeuroStructural Research Labs Inc., Tampa, Florida 33137, and
- 10Ottawa Health Research Institute, Department of Medicine, University of Ottawa, Ottawa, Ontario K1H 8M5, Canada
- Correspondence should be addressed to either of the following: Dr. Valter D. Longo, Andrus Gerontology Center, Department of Molecular and Computational Biology, University of Southern California, 3715 McClintock Avenue, Los Angeles, CA 90089-0191, vlongo{at}usc.edu; or Dr. Rafael de Cabo, Laboratory of Experimental Gerontology, National Institute on Aging, National Institutes of Health Gerontology Research Center, Box 10, 251 Bayview Boulevard, Suite 100/Room 9C218, Baltimore, MD 21224, E-mail: decabora{at}grc.nia.nih.gov
Author contributions
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↵*S.M. and Y.L. contributed equally to this work.
Disclosures
- Received January 4, 2010.
- Revision received April 26, 2010.
- Accepted May 27, 2010.
-
This research was supported by the University of Southern California National Institutes of Health (NIH) Alzheimer's Disease Research Center (V.D.L.), The Intramural Research Program of the NIH/National Institute on Aging (NIA) (R.d.C.), the Canadian Institutes of Health Research (M.W.M.), Juvenile Diabetes Research Foundation and Children's Hospital Boston, Manton Center (J.C.), and grants from NIH/NIA and NIH/National Institute of Neurological Disorders and Stroke (D.A.S.), NIH/National Eye Institute (EY017017 and EY017017 04S1), Roche Foundation for Anemia Research, and the MacTel Foundation (L.E.H.S.). D.A.S. is a senior scholar of the Ellison Medical Foundation. The mouse transgenic and behavioral work was supported by a gift from the Glenn Foundation for Medical Research to Harvard Medical School.
- Correspondence should be addressed to either of the following: Dr. Valter D. Longo, Andrus Gerontology Center, Department of Molecular and Computational Biology, University of Southern California, 3715 McClintock Avenue, Los Angeles, CA 90089-0191, vlongo{at}usc.edu; or Dr. Rafael de Cabo, Laboratory of Experimental Gerontology, National Institute on Aging, National Institutes of Health Gerontology Research Center, Box 10, 251 Bayview Boulevard, Suite 100/Room 9C218, Baltimore, MD 21224, E-mail: decabora{at}grc.nia.nih.gov
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