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Articles, Neurobiology of Disease

Coalescence and Fragmentation of Cortical Networks during Focal Seizures

Mark A. Kramer, Uri T. Eden, Eric D. Kolaczyk, Rodrigo Zepeda, Emad N. Eskandar and Sydney S. Cash
Journal of Neuroscience 28 July 2010, 30 (30) 10076-10085; DOI: https://doi.org/10.1523/JNEUROSCI.6309-09.2010
Mark A. Kramer
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Uri T. Eden
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Eric D. Kolaczyk
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Rodrigo Zepeda
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Emad N. Eskandar
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Sydney S. Cash
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Abstract

Epileptic seizures reflect a pathological brain state characterized by specific clinical and electrical manifestations. The proposed mechanisms are heterogeneous but united by the supposition that epileptic activity is hypersynchronous across multiple scales, yet principled and quantitative analyses of seizure dynamics across space and throughout the entire ictal period are rare. To more completely explore spatiotemporal interactions during seizures, we examined electrocorticogram data from a population of male and female human patients with epilepsy and from these data constructed dynamic network representations using statistically robust measures. We found that these networks evolved through a distinct topological progression during the seizure. Surprisingly, the overall synchronization changed only weakly, whereas the topology changed dramatically in organization. A large subnetwork dominated the network architecture at seizure onset and preceding termination but, between, fractured into smaller groups. Common network characteristics appeared consistently for a population of subjects, and, for each subject, similar networks appeared from seizure to seizure. These results suggest that, at the macroscopic spatial scale, epilepsy is not so much a manifestation of hypersynchrony but instead of network reorganization.

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The Journal of Neuroscience: 30 (30)
Journal of Neuroscience
Vol. 30, Issue 30
28 Jul 2010
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Coalescence and Fragmentation of Cortical Networks during Focal Seizures
Mark A. Kramer, Uri T. Eden, Eric D. Kolaczyk, Rodrigo Zepeda, Emad N. Eskandar, Sydney S. Cash
Journal of Neuroscience 28 July 2010, 30 (30) 10076-10085; DOI: 10.1523/JNEUROSCI.6309-09.2010

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Coalescence and Fragmentation of Cortical Networks during Focal Seizures
Mark A. Kramer, Uri T. Eden, Eric D. Kolaczyk, Rodrigo Zepeda, Emad N. Eskandar, Sydney S. Cash
Journal of Neuroscience 28 July 2010, 30 (30) 10076-10085; DOI: 10.1523/JNEUROSCI.6309-09.2010
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