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Featured ArticleArticles, Neurobiology of Disease

Excess Phosphoinositide 3-Kinase Subunit Synthesis and Activity as a Novel Therapeutic Target in Fragile X Syndrome

Christina Gross, Mika Nakamoto, Xiaodi Yao, Chi-Bun Chan, So Y. Yim, Keqiang Ye, Stephen T. Warren and Gary J. Bassell
Journal of Neuroscience 11 August 2010, 30 (32) 10624-10638; DOI: https://doi.org/10.1523/JNEUROSCI.0402-10.2010
Christina Gross
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Mika Nakamoto
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Xiaodi Yao
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Chi-Bun Chan
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So Y. Yim
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Keqiang Ye
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Stephen T. Warren
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Gary J. Bassell
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Article Information

DOI 
https://doi.org/10.1523/JNEUROSCI.0402-10.2010
PubMed 
20702695
Published By 
Society for Neuroscience
History 
  • Received January 24, 2010
  • Revision received May 9, 2010
  • Accepted June 11, 2010
  • First published August 11, 2010.
  • Version of record published August 11, 2010.
Copyright & Usage 
Copyright © 2010 the authors 0270-6474/10/3010624-15$15.00/0

Author Information

  1. Christina Gross 1 ,
  2. Mika Nakamoto 2 ,*,
  3. Xiaodi Yao 1 ,*,
  4. Chi-Bun Chan 3 ,
  5. So Y. Yim 1 ,
  6. Keqiang Ye 3 ,
  7. Stephen T. Warren 2 , 4 , 5 , and
  8. Gary J. Bassell 1 , 6
  1. Departments of 1Cell Biology,
  2. 2Human Genetics,
  3. 3Pathology and Laboratory Medicine,
  4. 4Biochemistry,
  5. 5Pediatrics, and
  6. 6Neurology, Emory University School of Medicine, Atlanta, Georgia 30322
  1. Correspondence should be addressed to Gary J. Bassell, Department of Cell Biology, Emory University, 615 Michael Street, Atlanta, GA 30322. gbassel{at}emory.edu
View Full Text

Author contributions

  1. ↵*M.N. and X.Y. contributed equally to this work.

View Abstract

Disclosures

    • Received January 24, 2010.
    • Revision received May 9, 2010.
    • Accepted June 11, 2010.
  • This work was supported by a postdoctoral fellowship and Conquer Fragile X research grant from the National Fragile X Foundation (C.G.), National Institutes of Health Grants MH085617 (G.J.B.) and HD020521 (S.T.W.), and Fragile X Center Grant 3P30HD024064 (S.T.W., G.J.B.). We thank Dr. Ravi Muddashetty for technical assistance with polysome assays and qRT-PCRs and helpful discussions, Andrew Swanson for technical assistance with microscopes and image processing, Adam Goldberg and Mary Roth for technical assistance, Sharon Swanger for help with colocalization analyses, statistics, and critically reading this manuscript, and all members of the Bassell laboratories for helpful discussions. We are grateful to Jennifer Darnell for providing the 2F5-1 antibody.

  • Correspondence should be addressed to Gary J. Bassell, Department of Cell Biology, Emory University, 615 Michael Street, Atlanta, GA 30322. gbassel{at}emory.edu

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Total 20131026354245
Jan 2014603114
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May 201438149
Jun 2014752611
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Total 2014754311143
Jan 2015441719
Feb 2015491811
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Apr 20154488
May 201543105
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Total 2016359212132
Jan 201735212
Feb 201749710
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Sep 201713619
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Total 201755676186
Jan 2018106311
Feb 201864711
Mar 20180288
Apr 201873017
May 201843212
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Aug 20183308
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Oct 2018115208
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Total 2018671372140
Jan 2019102914
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Total 2019217444140
Jan 202010397
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Total 202099310154
Jan 202122320
Total 202122320
Total693357682955
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The Journal of Neuroscience: 30 (32)
Journal of Neuroscience
Vol. 30, Issue 32
11 Aug 2010
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Excess Phosphoinositide 3-Kinase Subunit Synthesis and Activity as a Novel Therapeutic Target in Fragile X Syndrome
Christina Gross, Mika Nakamoto, Xiaodi Yao, Chi-Bun Chan, So Y. Yim, Keqiang Ye, Stephen T. Warren, Gary J. Bassell
Journal of Neuroscience 11 August 2010, 30 (32) 10624-10638; DOI: 10.1523/JNEUROSCI.0402-10.2010

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Excess Phosphoinositide 3-Kinase Subunit Synthesis and Activity as a Novel Therapeutic Target in Fragile X Syndrome
Christina Gross, Mika Nakamoto, Xiaodi Yao, Chi-Bun Chan, So Y. Yim, Keqiang Ye, Stephen T. Warren, Gary J. Bassell
Journal of Neuroscience 11 August 2010, 30 (32) 10624-10638; DOI: 10.1523/JNEUROSCI.0402-10.2010
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