Article Information
- Received July 25, 2010
- Accepted August 11, 2010
- First published September 29, 2010.
- Version of record published September 29, 2010.
Author Information
- Rachel F. Lane1,2,*,
- Summer M. Raines3,*,
- John W. Steele1,2,
- Michelle E. Ehrlich4,
- James A. Lah5,
- Scott A. Small6,
- Rudolph E. Tanzi7,
- Alan D. Attie3, and
- Sam Gandy1,2
- 1Departments of Neurology and Psychiatry and Alzheimer's Disease Research Center, Mount Sinai School of Medicine, New York, New York 10029,
- 2James J. Peters Veterans Affairs Medical Center, Bronx, New York 10468,
- 3Department of Biochemistry, University of Wisconsin, Madison, Wisconsin 53706,
- 4Departments of Pediatrics and Neurology, Mount Sinai School of Medicine, New York, New York 10029,
- 5Department of Neurology and Center for Neurodegenerative Disease, Emory University, Atlanta, Georgia 30322,
- 6Departments of Neurology, Neuroscience, and Pathology and Cell Biology, College of Physicians and Surgeons, Columbia University, New York, New York 10032, and
- 7Genetics and Aging Unit, Massachusetts General Hospital and Department of Neurology, Harvard Medical School, Charlestown, Massachusetts 02129
- Correspondence should be addressed to Dr. Sam Gandy, Departments of Neurology and Psychiatry, Mount Sinai School of Medicine, One Gustave L. Levy Place, Box 1137, New York, NY 10029. samuel.gandy{at}mssm.edu
Author contributions
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↵*R.F.L. and S.M.R. contributed equally to this work.
Disclosures
- Received July 25, 2010.
- Accepted August 11, 2010.
-
J.W.S. is a trainee in the Integrated Pharmacological Sciences Training Program supported by Grant T32GM06754 from the National Institute of General Medical Sciences. This work was supported by National Institute on Aging Grant P01AG10491 (to S.G.), Veterans Affairs Merit Review Grant 1I01BX000348 (S.G.), and National Institute of Diabetes and Digestive and Kidney Diseases Grant DK58037 (A.D.A.). S.G. and R.E.T. are members of the Cure Alzheimer's Fund (CAF) Research Consortium and acknowledge the support of CAF. Confocal laser scanning microscopy was performed at the Mount Sinai School of Medicine-Microscopy Shared Resource Facility, supported with funding from a National Institutes of Health (NIH)–National Cancer Institute Shared Resources Grant (5R24 CA095823-04), a National Science Foundation Major Research Instrumentation Grant (DBI-9724504), and an NIH Shared Instrumentation Grant (1 S10 RR0 9145-01). We thank Efrat Levy (New York University), Gopal Thinakaran (University of Chicago), and Nabil Seidah (Clinical Research Institute, Montreal) for cDNA constructs.
- Correspondence should be addressed to Dr. Sam Gandy, Departments of Neurology and Psychiatry, Mount Sinai School of Medicine, One Gustave L. Levy Place, Box 1137, New York, NY 10029. samuel.gandy{at}mssm.edu
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