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Brief Communications

Diabetes-Associated SorCS1 Regulates Alzheimer's Amyloid-β Metabolism: Evidence for Involvement of SorL1 and the Retromer Complex

Rachel F. Lane, Summer M. Raines, John W. Steele, Michelle E. Ehrlich, James A. Lah, Scott A. Small, Rudolph E. Tanzi, Alan D. Attie and Sam Gandy
Journal of Neuroscience 29 September 2010, 30 (39) 13110-13115; DOI: https://doi.org/10.1523/JNEUROSCI.3872-10.2010
Rachel F. Lane
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Summer M. Raines
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John W. Steele
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Michelle E. Ehrlich
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James A. Lah
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Scott A. Small
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Rudolph E. Tanzi
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Alan D. Attie
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Sam Gandy
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Article Information

DOI 
https://doi.org/10.1523/JNEUROSCI.3872-10.2010
PubMed 
20881129
Published By 
Society for Neuroscience
History 
  • Received July 25, 2010
  • Accepted August 11, 2010
  • First published September 29, 2010.
  • Version of record published September 29, 2010.
Copyright & Usage 
Copyright © 2010 the authors 0270-6474/10/3013110-06$15.00/0 This article is freely available online through the J Neurosci Open Choice option.

Author Information

  1. Rachel F. Lane1,2,*,
  2. Summer M. Raines3,*,
  3. John W. Steele1,2,
  4. Michelle E. Ehrlich4,
  5. James A. Lah5,
  6. Scott A. Small6,
  7. Rudolph E. Tanzi7,
  8. Alan D. Attie3, and
  9. Sam Gandy1,2
  1. 1Departments of Neurology and Psychiatry and Alzheimer's Disease Research Center, Mount Sinai School of Medicine, New York, New York 10029,
  2. 2James J. Peters Veterans Affairs Medical Center, Bronx, New York 10468,
  3. 3Department of Biochemistry, University of Wisconsin, Madison, Wisconsin 53706,
  4. 4Departments of Pediatrics and Neurology, Mount Sinai School of Medicine, New York, New York 10029,
  5. 5Department of Neurology and Center for Neurodegenerative Disease, Emory University, Atlanta, Georgia 30322,
  6. 6Departments of Neurology, Neuroscience, and Pathology and Cell Biology, College of Physicians and Surgeons, Columbia University, New York, New York 10032, and
  7. 7Genetics and Aging Unit, Massachusetts General Hospital and Department of Neurology, Harvard Medical School, Charlestown, Massachusetts 02129
  1. Correspondence should be addressed to Dr. Sam Gandy, Departments of Neurology and Psychiatry, Mount Sinai School of Medicine, One Gustave L. Levy Place, Box 1137, New York, NY 10029. samuel.gandy{at}mssm.edu
View Full Text

Author contributions

  1. ↵*R.F.L. and S.M.R. contributed equally to this work.

View Abstract

Disclosures

    • Received July 25, 2010.
    • Accepted August 11, 2010.
  • J.W.S. is a trainee in the Integrated Pharmacological Sciences Training Program supported by Grant T32GM06754 from the National Institute of General Medical Sciences. This work was supported by National Institute on Aging Grant P01AG10491 (to S.G.), Veterans Affairs Merit Review Grant 1I01BX000348 (S.G.), and National Institute of Diabetes and Digestive and Kidney Diseases Grant DK58037 (A.D.A.). S.G. and R.E.T. are members of the Cure Alzheimer's Fund (CAF) Research Consortium and acknowledge the support of CAF. Confocal laser scanning microscopy was performed at the Mount Sinai School of Medicine-Microscopy Shared Resource Facility, supported with funding from a National Institutes of Health (NIH)–National Cancer Institute Shared Resources Grant (5R24 CA095823-04), a National Science Foundation Major Research Instrumentation Grant (DBI-9724504), and an NIH Shared Instrumentation Grant (1 S10 RR0 9145-01). We thank Efrat Levy (New York University), Gopal Thinakaran (University of Chicago), and Nabil Seidah (Clinical Research Institute, Montreal) for cDNA constructs.

  • Correspondence should be addressed to Dr. Sam Gandy, Departments of Neurology and Psychiatry, Mount Sinai School of Medicine, One Gustave L. Levy Place, Box 1137, New York, NY 10029. samuel.gandy{at}mssm.edu

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Article usage: September 2010 to January 2021

AbstractFullPdf
Sep 201025947182
Oct 2010201430536
Nov 201085190187
Dec 201031134100
Total 20105768011005
Jan 20114510883
Feb 2011487969
Mar 2011857670
Apr 2011637443
May 2011519567
Jun 2011407749
Jul 2011507571
Aug 2011548061
Sep 2011689756
Oct 2011547469
Nov 2011886457
Dec 2011614246
Total 2011707941741
Jan 2012554634
Feb 2012795238
Mar 2012713831
Apr 2012644525
May 2012684226
Jun 2012532819
Jul 2012413519
Aug 2012362819
Sep 2012482323
Oct 2012792238
Nov 2012814535
Dec 2012682120
Total 2012743425327
Jan 2013573527
Feb 2013442724
Mar 2013573221
Apr 2013453133
May 2013482729
Jun 2013521010
Jul 2013512420
Aug 2013341815
Sep 201341179
Oct 2013432223
Nov 2013492127
Dec 2013301814
Total 2013551282252
Jan 2014431713
Feb 2014581624
Mar 2014351422
Apr 2014332524
May 2014436419
Jun 20144275
Jul 2014362311
Aug 2014351015
Sep 2014472118
Oct 201440168
Nov 2014272013
Dec 20143497
Total 2014473242179
Jan 2015341212
Feb 201523137
Mar 201544239
Apr 2015351510
May 201528159
Jun 2015301215
Jul 2015231614
Aug 201526106
Sep 2015342023
Oct 2015421513
Nov 2015262719
Dec 20152145
Total 2015366182142
Jan 201621158
Feb 2016201112
Mar 2016471723
Apr 2016331313
May 2016271310
Jun 201620103
Jul 20162587
Aug 201624158
Sep 2016291816
Oct 2016172110
Nov 201671612
Dec 20162254
Total 2016272182126
Jan 201711438
Feb 201762410
Mar 20179225
Apr 201753815
May 201710488
Jun 20174194
Jul 20171144
Aug 201791715
Sep 20172144
Oct 20175277
Nov 20173183
Dec 20175321
Total 20177031684
Jan 20184253
Feb 201881413
Mar 20183215
Apr 201841686
May 201823004
Jun 20186366
Jul 201811608
Aug 20182515
Sep 20183306
Oct 20182449
Nov 201885011
Dec 201864311
Total 20185984287
Jan 201903812
Feb 2019103312
Mar 201962613
Apr 201961612
May 201910209
Jun 201912111
Jul 20193175
Aug 201902210
Sep 20196296
Oct 20192525
Nov 201942311
Dec 20196146
Total 201954311112
Jan 20209196
Feb 202031917
Mar 202042512
Apr 202062013
May 202023111
Jun 20200284
Jul 20204173
Aug 20202125
Sep 20203296
Oct 202064521
Nov 202056021
Dec 20208326
Total 202052337125
Jan 202110279
Total 202110279
Total393348883189
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The Journal of Neuroscience: 30 (39)
Journal of Neuroscience
Vol. 30, Issue 39
29 Sep 2010
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Diabetes-Associated SorCS1 Regulates Alzheimer's Amyloid-β Metabolism: Evidence for Involvement of SorL1 and the Retromer Complex
Rachel F. Lane, Summer M. Raines, John W. Steele, Michelle E. Ehrlich, James A. Lah, Scott A. Small, Rudolph E. Tanzi, Alan D. Attie, Sam Gandy
Journal of Neuroscience 29 September 2010, 30 (39) 13110-13115; DOI: 10.1523/JNEUROSCI.3872-10.2010

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Diabetes-Associated SorCS1 Regulates Alzheimer's Amyloid-β Metabolism: Evidence for Involvement of SorL1 and the Retromer Complex
Rachel F. Lane, Summer M. Raines, John W. Steele, Michelle E. Ehrlich, James A. Lah, Scott A. Small, Rudolph E. Tanzi, Alan D. Attie, Sam Gandy
Journal of Neuroscience 29 September 2010, 30 (39) 13110-13115; DOI: 10.1523/JNEUROSCI.3872-10.2010
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