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Articles, Behavioral/Systems/Cognitive

Distinct Modulatory Effects of Satiety and Sibutramine on Brain Responses to Food Images in Humans: A Double Dissociation across Hypothalamus, Amygdala, and Ventral Striatum

Paul C. Fletcher, Antonella Napolitano, Andrew Skeggs, Sam R. Miller, Bruno Delafont, Victoria C. Cambridge, Sanne de Wit, Pradeep J. Nathan, Allison Brooke, Stephen O'Rahilly, I. Sadaf Farooqi and Edward T. Bullmore
Journal of Neuroscience 27 October 2010, 30 (43) 14346-14355; https://doi.org/10.1523/JNEUROSCI.3323-10.2010
Paul C. Fletcher
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Antonella Napolitano
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Andrew Skeggs
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Sam R. Miller
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Bruno Delafont
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Victoria C. Cambridge
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Sanne de Wit
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Pradeep J. Nathan
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Allison Brooke
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Stephen O'Rahilly
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I. Sadaf Farooqi
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Edward T. Bullmore
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Abstract

We used functional magnetic resonance imaging to explore brain responses to food images in overweight humans, examining independently the impact of a prescan meal (“satiety”) and the anti-obesity drug sibutramine, a serotonin and noradrenaline reuptake inhibitor. We identified significantly different responses to these manipulations in amygdala, hypothalamus, and ventral striatum. Each region was specifically responsive to high-calorie compared to low-calorie food images. However, the ventral striatal response was attenuated by satiety (but unaffected by sibutramine), while the hypothalamic and amygdala responses were attenuated by drug but unaffected by satiety. Direct assessment of regional interactions confirmed the significance of this double dissociation. We explored the regional responses in greater detail by determining whether they were predictive of eating behavior and weight change. We observed that across the different regions, the individual-specific magnitude of drug- and satiety-induced modulation was associated with both variables: the sibutramine-induced modulation of the hypothalamic response was correlated with the drug's impact on both weight and subsequently measured ad libitum eating. The satiety-induced modulation of striatal response also correlated with subsequent ad libitum eating. These results suggest that hypothalamus and amygdala have roles in the control of food intake that are distinct from those of ventral striatum. Furthermore, they support a regionally specific effect on brain function through which sibutramine exerts its clinical effect.

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The Journal of Neuroscience: 30 (43)
Journal of Neuroscience
Vol. 30, Issue 43
27 Oct 2010
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Distinct Modulatory Effects of Satiety and Sibutramine on Brain Responses to Food Images in Humans: A Double Dissociation across Hypothalamus, Amygdala, and Ventral Striatum
Paul C. Fletcher, Antonella Napolitano, Andrew Skeggs, Sam R. Miller, Bruno Delafont, Victoria C. Cambridge, Sanne de Wit, Pradeep J. Nathan, Allison Brooke, Stephen O'Rahilly, I. Sadaf Farooqi, Edward T. Bullmore
Journal of Neuroscience 27 October 2010, 30 (43) 14346-14355; DOI: 10.1523/JNEUROSCI.3323-10.2010

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Distinct Modulatory Effects of Satiety and Sibutramine on Brain Responses to Food Images in Humans: A Double Dissociation across Hypothalamus, Amygdala, and Ventral Striatum
Paul C. Fletcher, Antonella Napolitano, Andrew Skeggs, Sam R. Miller, Bruno Delafont, Victoria C. Cambridge, Sanne de Wit, Pradeep J. Nathan, Allison Brooke, Stephen O'Rahilly, I. Sadaf Farooqi, Edward T. Bullmore
Journal of Neuroscience 27 October 2010, 30 (43) 14346-14355; DOI: 10.1523/JNEUROSCI.3323-10.2010
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