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Articles, Behavioral/Systems/Cognitive

Distinct Modulatory Effects of Satiety and Sibutramine on Brain Responses to Food Images in Humans: A Double Dissociation across Hypothalamus, Amygdala, and Ventral Striatum

Paul C. Fletcher, Antonella Napolitano, Andrew Skeggs, Sam R. Miller, Bruno Delafont, Victoria C. Cambridge, Sanne de Wit, Pradeep J. Nathan, Allison Brooke, Stephen O'Rahilly, I. Sadaf Farooqi and Edward T. Bullmore
Journal of Neuroscience 27 October 2010, 30 (43) 14346-14355; https://doi.org/10.1523/JNEUROSCI.3323-10.2010
Paul C. Fletcher
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Antonella Napolitano
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Andrew Skeggs
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Sam R. Miller
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Bruno Delafont
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Victoria C. Cambridge
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Sanne de Wit
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Pradeep J. Nathan
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Allison Brooke
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Stephen O'Rahilly
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I. Sadaf Farooqi
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Edward T. Bullmore
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Article Information

DOI 
https://doi.org/10.1523/JNEUROSCI.3323-10.2010
PubMed 
20980590
Published By 
Society for Neuroscience
History 
  • Received June 28, 2010
  • Revision received August 18, 2010
  • Accepted August 27, 2010
  • First published October 27, 2010.
  • Version of record published October 27, 2010.
Copyright & Usage 
Copyright © 2010 the authors 0270-6474/10/3014346-10$15.00/0

Author Information

  1. Paul C. Fletcher1,
  2. Antonella Napolitano2,
  3. Andrew Skeggs2,
  4. Sam R. Miller2,
  5. Bruno Delafont2,
  6. Victoria C. Cambridge1,
  7. Sanne de Wit3,
  8. Pradeep J. Nathan1,2,
  9. Allison Brooke2,
  10. Stephen O'Rahilly4,
  11. I. Sadaf Farooqi4, and
  12. Edward T. Bullmore1,2
  1. 1Department of Psychiatry, University of Cambridge, Cambridge CB2 0SZ, United Kingdom,
  2. 2GlaxoSmithKline Clinical Unit Cambridge, Addenbrooke's Centre for Clinical Investigations, Addenbrooke's Hospital, Cambridge CB2 2QQ, United Kingdom,
  3. 3Amsterdam Center for the Study of Adaptive Control in Brain and Behavior, Department of Developmental Psychology, University of Amsterdam, 1018 WB Amsterdam, The Netherlands, and
  4. 4University of Cambridge Metabolic Research Laboratories, Institute of Metabolic Science, Addenbrooke's Hospital, Cambridge CB2 2QQ, United Kingdom
  1. Correspondence should be addressed to either of the following: I. Sadaf Farooqi, University of Cambridge Metabolic Research Laboratories, Institute of Metabolic Science, Addenbrooke's Hospital, Cambridge CB2 2QQ, UK, isf20{at}cam.ac.uk; or Paul C. Fletcher, Department of Psychiatry, University of Cambridge, Herchel Smith Building for Brain and Mind Sciences, Cambridge CB2 0SZ, UK, E-mail: pcf22{at}cam.ac.uk
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Author contributions

Disclosures

    • Received June 28, 2010.
    • Revision received August 18, 2010.
    • Accepted August 27, 2010.
  • The study was sponsored by GlaxoSmithKline. P.C.F. was supported by the Wellcome Trust and by the Bernard Wolfe Health Neuroscience Fund. S.O.R. and I.S.F. were supported by the Wellcome Trust, Medical Research Council (MRC) Centre for Obesity and Related Disorders, and National Institute for Health Research Cambridge Biomedical Research Centre. The work was also carried out in the MRC- and Wellcome Trust-funded Behavioural and Clinical Neurosciences Institute.

  • Correspondence should be addressed to either of the following: I. Sadaf Farooqi, University of Cambridge Metabolic Research Laboratories, Institute of Metabolic Science, Addenbrooke's Hospital, Cambridge CB2 2QQ, UK, isf20{at}cam.ac.uk; or Paul C. Fletcher, Department of Psychiatry, University of Cambridge, Herchel Smith Building for Brain and Mind Sciences, Cambridge CB2 0SZ, UK, E-mail: pcf22{at}cam.ac.uk

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Total 20253521374
Total4452961738
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The Journal of Neuroscience: 30 (43)
Journal of Neuroscience
Vol. 30, Issue 43
27 Oct 2010
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Distinct Modulatory Effects of Satiety and Sibutramine on Brain Responses to Food Images in Humans: A Double Dissociation across Hypothalamus, Amygdala, and Ventral Striatum
Paul C. Fletcher, Antonella Napolitano, Andrew Skeggs, Sam R. Miller, Bruno Delafont, Victoria C. Cambridge, Sanne de Wit, Pradeep J. Nathan, Allison Brooke, Stephen O'Rahilly, I. Sadaf Farooqi, Edward T. Bullmore
Journal of Neuroscience 27 October 2010, 30 (43) 14346-14355; DOI: 10.1523/JNEUROSCI.3323-10.2010

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Distinct Modulatory Effects of Satiety and Sibutramine on Brain Responses to Food Images in Humans: A Double Dissociation across Hypothalamus, Amygdala, and Ventral Striatum
Paul C. Fletcher, Antonella Napolitano, Andrew Skeggs, Sam R. Miller, Bruno Delafont, Victoria C. Cambridge, Sanne de Wit, Pradeep J. Nathan, Allison Brooke, Stephen O'Rahilly, I. Sadaf Farooqi, Edward T. Bullmore
Journal of Neuroscience 27 October 2010, 30 (43) 14346-14355; DOI: 10.1523/JNEUROSCI.3323-10.2010
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