Skip to main content

Main menu

  • HOME
  • CONTENT
    • Early Release
    • Featured
    • Current Issue
    • Issue Archive
    • Collections
    • Podcast
  • ALERTS
  • FOR AUTHORS
    • Information for Authors
    • Fees
    • Journal Clubs
    • eLetters
    • Submit
    • Special Collections
  • EDITORIAL BOARD
    • Editorial Board
    • ECR Advisory Board
    • Journal Staff
  • ABOUT
    • Overview
    • Advertise
    • For the Media
    • Rights and Permissions
    • Privacy Policy
    • Feedback
    • Accessibility
  • SUBSCRIBE

User menu

  • Log out
  • Log in
  • My Cart

Search

  • Advanced search
Journal of Neuroscience
  • Log out
  • Log in
  • My Cart
Journal of Neuroscience

Advanced Search

Submit a Manuscript
  • HOME
  • CONTENT
    • Early Release
    • Featured
    • Current Issue
    • Issue Archive
    • Collections
    • Podcast
  • ALERTS
  • FOR AUTHORS
    • Information for Authors
    • Fees
    • Journal Clubs
    • eLetters
    • Submit
    • Special Collections
  • EDITORIAL BOARD
    • Editorial Board
    • ECR Advisory Board
    • Journal Staff
  • ABOUT
    • Overview
    • Advertise
    • For the Media
    • Rights and Permissions
    • Privacy Policy
    • Feedback
    • Accessibility
  • SUBSCRIBE
PreviousNext
Articles, Behavioral/Systems/Cognitive

Distinct Modulatory Effects of Satiety and Sibutramine on Brain Responses to Food Images in Humans: A Double Dissociation across Hypothalamus, Amygdala, and Ventral Striatum

Paul C. Fletcher, Antonella Napolitano, Andrew Skeggs, Sam R. Miller, Bruno Delafont, Victoria C. Cambridge, Sanne de Wit, Pradeep J. Nathan, Allison Brooke, Stephen O'Rahilly, I. Sadaf Farooqi and Edward T. Bullmore
Journal of Neuroscience 27 October 2010, 30 (43) 14346-14355; https://doi.org/10.1523/JNEUROSCI.3323-10.2010
Paul C. Fletcher
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Antonella Napolitano
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Andrew Skeggs
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Sam R. Miller
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Bruno Delafont
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Victoria C. Cambridge
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Sanne de Wit
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Pradeep J. Nathan
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Allison Brooke
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Stephen O'Rahilly
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
I. Sadaf Farooqi
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Edward T. Bullmore
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • Article
  • Figures & Data
  • Info & Metrics
  • eLetters
  • PDF
Loading

Article Figures & Data

Figures

  • Tables
  • Additional Files
  • Figure 1.
    • Download figure
    • Open in new tab
    • Download powerpoint
    Figure 1.

    Schematic of study design.

  • Figure 2.
    • Download figure
    • Open in new tab
    • Download powerpoint
    Figure 2.

    Brain activations in response to high-calorie food images, and modulations by sibutramine and satiety. Coronal (at y = −14 mm, −4 mm, +2 mm, and +6 mm relative to the anterior commissure) and sagittal (at x = +6 mm, +8 mm, +22 mm, and +8 mm to the right of the midline) sections from the group average structural image are shown. Superimposed on these in red are significant activations from the comparison between high- and low-calorie food images (all surviving p < 0.05, familywise error correction for multiple comparisons). Key regions showing this effect were insula, striatum [including putamen and globus pallidus (Put/Pall)], midbrain, amygdala, and hypothalamus. Superimposed in yellow is the region of ventral striatum (VS) showing a significantly greater response in the fasted state. In green are those regions—hypothalamus (Hy) and amygdala (Amyg)—that showed a stimulus-type-by-drug interaction, i.e., significant reduction in high-calorie stimulus-related activation following treatment with sibutramine (compared to placebo). The interactions threshold is p < 0.01, uncorrected, for display.

  • Figure 3.
    • Download figure
    • Open in new tab
    • Download powerpoint
    Figure 3.

    Right ventral striatal response showing attenuation of calorie-specific response by satiety. Top left, A coronal section of the group average structural MRI at 6 mm anterior to the anterior commissure. Superimposed in red are the local regions showing a calorie-specific (high-calorie vs low-calorie images) effect (p < 0.05, corrected), and in yellow is the region of ventral striatum (p < 0.01 uncorrected) in which this calorie-specific response is significantly greater in the fasted than the fed state. Top right, The plots show estimates of stimulus-related brain activation for each of the eight key conditions, divided by image type (high calorie/low calorie), satiety state (fasted/fed), and treatment (sibutramine/placebo). The y-axis show the effect sizes in the ventral striatal region as parameter estimates derived from the general linear model (units are arbitrary). As can be seen there is a strong effect of image type and of fasted state but no drug effect. Bottom, Scatter plot showing the association between the fasted versus fed effect for high-calorie compared to low-calorie images in ventral striatum and the subsequent weight of popcorn consumed in the ad libitum snack test. As can be seen, the greater the striatal response to high-calorie images under fasting conditions, the greater the subsequent consumption.

  • Figure 4.
    • Download figure
    • Open in new tab
    • Download powerpoint
    Figure 4.

    a, Hypothalamic responses to experimental manipulations (image type and sibutramine status). Top left, A coronal section of the group average structural MRI at 4 mm posterior to the anterior commissure. Superimposed in red are the local regions showing a calorie-specific (high-calorie vs low-calorie images) effect (p < 0.05, corrected), and in green (p < 0.01, uncorrected) are the hypothalamic regions in which this calorie-specific response is significantly attenuated by sibutramine. Top right, The plots show estimates of stimulus-related brain activation for each of the eight key conditions, divided by image type (high calorie/low calorie), satiety state (fasted/fed), and treatment (sibutramine/placebo). The y-axes show the effect sizes in the ventral striatal region shown or parameter estimates derived from the general linear model (units are arbitrary). As can be seen there is a strong effect of image type and of sibutramine but not of fasted/fed state. Bottom, Scatter plots showing the associations between the effect of sibutramine on suppression of hypothalamic activation by high-calorie food images (x-axis) and its effects on the proportion of ad libitum popcorn consumed on sibutramine compared to placebo (left) and on body weight in kilograms (right). In both graphs, a value of greater than zero on the x-axis indicates a suppression of activation on sibutramine compared to placebo; a value of less than zero on the y-axis indicates that there was a greater reduction in snacking or weight for sibutramine compared with for placebo. The graphs show that participants who demonstrated greater suppression of hypothalamic activation by sibutramine also showed greater treatment-related reduction in popcorn snacking and body weight. b, Amygdala responses to experimental manipulations (image type and sibutramine status). Left, A coronal section of the group average structural MRI at 2 mm anterior to the anterior commissure. Superimposed in red are the local regions showing a calorie-specific (high-calorie vs low-calorie images) response (p < 0.05, corrected), and in green (at crosshairs) is the amygdala region in which this calorie-specific response is significantly attenuated by sibutramine (p < 0.01, uncorrected). Right, The plots show estimates of stimulus-related brain activation for each of the eight key conditions, divided by image type (high calorie/low calorie), satiety state (fasted/fed), and treatment (sibutramine/placebo). The y-axis show the effect sizes in the ventral striatal region shown or parameter estimates derived from the general linear model (units are arbitrary). As can be seen, there is a strong effect of image type and of sibutramine but not of fasted/fed state.

Tables

  • Figures
  • Additional Files
    • View popup
    Table 1.

    Scanned sample characteristics

    Subjects undergoing fMRI (24)
    Age (years)
        Mean (SD)34.9 (6.89)
        Range22–44
    Sex
        Male19 (79%)
        Female5 (21%)
    Ethnicity
        Black0 (0%)
        Caucasian22 (92%)
        Other2 (8%)
    Weight (kg)
        Mean (SD)85.2 (7.54)
        Range71.3–102.5
    BMI (kg/m2)
        Mean (SD)27.06 (1.40)
        Range25.3–30.6
    Fat mass (kg)
        Mean (SD)21.1 (6.63)
        Range9.7–39.4
    Barratt Impulsiveness Scale
        Mean (SD)62.1 (7.58)
        Range47–79
    • View popup
    Table 2.

    Effects of sibutramine

    SibutraminePlaceboDifference95% CItdfp value
    MeanSDMeanSD
    Change in fat mass (kg)−0.760.550.040.62−0.79(−1.14, −0.44)4.641<0.0001
    Change in weight (kg)−1.851.19−0.311.07−1.56(−2.27, −0.86)4.539<0.0001
    Eating rate (g/min)27.58.929.210.4−2.6(−6.5, 1.3)1.418.50.1742
    HCFQ total score18.02.620.82.7−2.9(−4.2, −1.6)4.721.60.0001
    Ad libitum eating (g)53.343.871.744.7−15.7(−30.8, −0.5)2.220.90.0430
    • View popup
    Table 3.

    Greater brain responses to high-calorie than to low-calorie images (across all fasted/fed and drug/placebo conditions)

    RegionCoordinates (x, y, z)Z score
    Ventral pallidum/putamen
        Left−12, 2, 47.3
    −24, −18, 46.1
        Right12, 2, 27
    Hypothalamus
        Left−10, −2, −46.2
        Right8, −4, −36
    Ventral striatum
        Right10, 4, 27
        Left−10, 2, 06.9
    Midbrain (substantia nigra/red nucleus)
        Right6, −14, −35.5
        Left−8, −20, −105.3
    Amygdala
        Left−26, −3, −155.9
    −18, −12, −94.1
        Right22, 1, −175.7
    20, −12, −103.6
    Insula
        Right32, 11, −65
    42, 17, −15
    36, 23, 14.5
        Left−42, 17, −34.8
    −32, 10, 024.3
    • All regions survived small volume correction for multiple comparisons.

Additional Files

  • Figures
  • Tables
  • Supplemental Material

    Files in this Data Supplement:

    • supplemental material - Supplemental Material
Back to top

In this issue

The Journal of Neuroscience: 30 (43)
Journal of Neuroscience
Vol. 30, Issue 43
27 Oct 2010
  • Table of Contents
  • Table of Contents (PDF)
  • About the Cover
  • Index by author
  • Advertising (PDF)
  • Ed Board (PDF)
Email

Thank you for sharing this Journal of Neuroscience article.

NOTE: We request your email address only to inform the recipient that it was you who recommended this article, and that it is not junk mail. We do not retain these email addresses.

Enter multiple addresses on separate lines or separate them with commas.
Distinct Modulatory Effects of Satiety and Sibutramine on Brain Responses to Food Images in Humans: A Double Dissociation across Hypothalamus, Amygdala, and Ventral Striatum
(Your Name) has forwarded a page to you from Journal of Neuroscience
(Your Name) thought you would be interested in this article in Journal of Neuroscience.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
Print
View Full Page PDF
Citation Tools
Distinct Modulatory Effects of Satiety and Sibutramine on Brain Responses to Food Images in Humans: A Double Dissociation across Hypothalamus, Amygdala, and Ventral Striatum
Paul C. Fletcher, Antonella Napolitano, Andrew Skeggs, Sam R. Miller, Bruno Delafont, Victoria C. Cambridge, Sanne de Wit, Pradeep J. Nathan, Allison Brooke, Stephen O'Rahilly, I. Sadaf Farooqi, Edward T. Bullmore
Journal of Neuroscience 27 October 2010, 30 (43) 14346-14355; DOI: 10.1523/JNEUROSCI.3323-10.2010

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero
Respond to this article
Request Permissions
Share
Distinct Modulatory Effects of Satiety and Sibutramine on Brain Responses to Food Images in Humans: A Double Dissociation across Hypothalamus, Amygdala, and Ventral Striatum
Paul C. Fletcher, Antonella Napolitano, Andrew Skeggs, Sam R. Miller, Bruno Delafont, Victoria C. Cambridge, Sanne de Wit, Pradeep J. Nathan, Allison Brooke, Stephen O'Rahilly, I. Sadaf Farooqi, Edward T. Bullmore
Journal of Neuroscience 27 October 2010, 30 (43) 14346-14355; DOI: 10.1523/JNEUROSCI.3323-10.2010
Twitter logo Facebook logo Mendeley logo
  • Tweet Widget
  • Facebook Like
  • Google Plus One

Jump to section

  • Article
    • Abstract
    • Introduction
    • Materials and Methods
    • Results
    • Discussion
    • Footnotes
    • References
  • Figures & Data
  • Info & Metrics
  • eLetters
  • PDF

Responses to this article

Respond to this article

Jump to comment:

No eLetters have been published for this article.

Related Articles

Cited By...

More in this TOC Section

Articles

  • Memory Retrieval Has a Dynamic Influence on the Maintenance Mechanisms That Are Sensitive to ζ-Inhibitory Peptide (ZIP)
  • Neurophysiological Evidence for a Cortical Contribution to the Wakefulness-Related Drive to Breathe Explaining Hypocapnia-Resistant Ventilation in Humans
  • Monomeric Alpha-Synuclein Exerts a Physiological Role on Brain ATP Synthase
Show more Articles

Behavioral/Systems/Cognitive

  • Influence of Reward on Corticospinal Excitability during Movement Preparation
  • Identification and Characterization of a Sleep-Active Cell Group in the Rostral Medullary Brainstem
  • Gravin Orchestrates Protein Kinase A and β2-Adrenergic Receptor Signaling Critical for Synaptic Plasticity and Memory
Show more Behavioral/Systems/Cognitive
  • Home
  • Alerts
  • Follow SFN on BlueSky
  • Visit Society for Neuroscience on Facebook
  • Follow Society for Neuroscience on Twitter
  • Follow Society for Neuroscience on LinkedIn
  • Visit Society for Neuroscience on Youtube
  • Follow our RSS feeds

Content

  • Early Release
  • Current Issue
  • Issue Archive
  • Collections

Information

  • For Authors
  • For Advertisers
  • For the Media
  • For Subscribers

About

  • About the Journal
  • Editorial Board
  • Privacy Notice
  • Contact
  • Accessibility
(JNeurosci logo)
(SfN logo)

Copyright © 2025 by the Society for Neuroscience.
JNeurosci Online ISSN: 1529-2401

The ideas and opinions expressed in JNeurosci do not necessarily reflect those of SfN or the JNeurosci Editorial Board. Publication of an advertisement or other product mention in JNeurosci should not be construed as an endorsement of the manufacturer’s claims. SfN does not assume any responsibility for any injury and/or damage to persons or property arising from or related to any use of any material contained in JNeurosci.