Reelin Signals through Apolipoprotein E Receptor 2 and Cdc42 to Increase Growth Cone Motility and Filopodia Formation

This work was supported by the Deutsche Forschungsgemeinschaft, the Forschungskommission of the Medical Faculty of Freiburg University, and the Landesgraduiertenförderung of Baden-Württemberg. We thank J.G. Collard (The Netherlands Cancer Institute, Amsterdam, The Netherlands), M. Matsuda (Kyoto University, Kyoto, Japan) and F. Dai (Department of Anatomy, Freiburg University, Freiburg, Germany) for plasmids, J. Nimpf and N. Andrade (Max F. Perutz Laboratories, Vienna, Austria) for the a186 antibody, and T. Kirchhausen (Harvard University, Cambridge, MA) for secramine, S. Zhao (Department of Anatomy, Freiburg University, Freiburg, Germany) for hippocampal slice cultures, Gudula Schmidt (Institute of Pharmacology, Freiburg University, Freiburg, Germany) for CNF1, J. Göldner (Zentrum für Neurowissenschaften, Freiburg, Germany) for excellent technical assistance, H.E. Blum (Department of Internal Medicine II, Freiburg University, Freiburg, Germany) for support, and P. May (Zentrum für Neurowissenschaften, Freiburg University, Freiburg, Germany) for critical reading of the manuscript.