Figure 4.
Figure 4.
Cooling potentiates AITC- or 4-HNE-activated currents in isolated DRG neurons. A, B, Continuous whole-cell recordings at −60 mV from isolated rat DRG neurons. The temperature of the perfusion solutions was switched from 25°C (open horizontal bars) to 10°C (blue horizontal bars) both in absence of an agonist and in the presence of AITC (A) or 4-HNE (B). The currents activated by those two agonists were blocked by 20 μm HC-030031 (black horizontal bars). C, Quantification of the fold increase in inward current evoked by cooling from 25 to 10°C in the presence of AITC (30 μm) or 4-HNE (30 μm). The bars represent the mean ± SEM of four (AITC) or five (4-HNE) DRG neurons.
