Lgi4 Promotes the Proliferation and Differentiation of Glial Lineage Cells throughout the Developing Peripheral Nervous System

This work was supported by the Howard Hughes Medical Institute and National Institute of Neurological Disorders and Stroke Grant NS-040750-10. Flow cytometry was partially supported by the University of Michigan (UM) Comprehensive Cancer (UMCC) National Institutes of Health (NIH) Grant CA46592. Antibody production was supported in part by National Institute of Diabetes and Digestive and Kidney Diseases Grant NIH5P60-DK20572 [Michigan Diabetes Research and Training Center (MDRTC)]. Gene-targeted mouse production was partially supported by the MDRTC, UMCC, and UM–Gastrointestinal Hormone Research Core Center NIH Grant 5P30DK034933. J.N. was supported by a postdoctoral fellowship from the Japan Society for the Promotion of Science. Thanks to David Adams and Martin White for flow cytometry, to Elizabeth Smith (UM Hybridoma Core) for antibody production, and to Elizabeth Hughes and Keith Childs for the generation of Lgi4 knock-out mice. Thanks to P. Brophy (University of Edinburgh), T. Glaser (University of Michigan), and T. Muller (Max Delbruck Center) for sharing antibodies. Thanks to Dr. Masaki Fukada and Yoko Fukada for sharing ADAM-HA expression vectors.