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Featured ArticleArticles, Behavioral/Systems/Cognitive

Antidepressant Effect of Optogenetic Stimulation of the Medial Prefrontal Cortex

Herbert E. Covington III, Mary Kay Lobo, Ian Maze, Vincent Vialou, James M. Hyman, Samir Zaman, Quincey LaPlant, Ezekiel Mouzon, Subroto Ghose, Carol A. Tamminga, Rachael L. Neve, Karl Deisseroth and Eric J. Nestler
Journal of Neuroscience 1 December 2010, 30 (48) 16082-16090; DOI: https://doi.org/10.1523/JNEUROSCI.1731-10.2010
Herbert E. Covington III
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Mary Kay Lobo
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Ian Maze
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Vincent Vialou
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James M. Hyman
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Samir Zaman
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Quincey LaPlant
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Ezekiel Mouzon
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Subroto Ghose
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Carol A. Tamminga
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Rachael L. Neve
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Karl Deisseroth
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Eric J. Nestler
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Article Information

DOI 
https://doi.org/10.1523/JNEUROSCI.1731-10.2010
PubMed 
21123555
Published By 
Society for Neuroscience
History 
  • Received April 5, 2010
  • Revision received September 7, 2010
  • Accepted September 27, 2010
  • First published December 1, 2010.
  • Version of record published December 1, 2010.
Copyright & Usage 
Copyright © 2010 the authors 0270-6474/10/3016082-09$15.00/0

Author Information

  1. Herbert E. Covington III 1 ,
  2. Mary Kay Lobo 1 ,
  3. Ian Maze 1 ,
  4. Vincent Vialou 1 ,
  5. James M. Hyman 2 ,
  6. Samir Zaman 1 ,
  7. Quincey LaPlant 1 ,
  8. Ezekiel Mouzon 1 ,
  9. Subroto Ghose 3 ,
  10. Carol A. Tamminga 3 ,
  11. Rachael L. Neve 4 ,
  12. Karl Deisseroth 5 , and
  13. Eric J. Nestler 1
  1. 1Fishberg Department of Neuroscience, Mount Sinai School of Medicine, New York, New York 10029,
  2. 2Department of Psychiatry, University of British Columbia, Vancouver, British Columbia V6T 2B5, Canada,
  3. 3Department of Psychiatry, The University of Texas Southwestern Medical Center, Dallas, Texas 75390,
  4. 4Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, and
  5. 5Department of Bioengineering, Stanford University, Stanford, California 94305
  1. Correspondence should be addressed to Eric J. Nestler, Fishberg Department of Neuroscience, Mount Sinai School of Medicine, One Gustave L. Levy Place, Box 1065, New York, NY 10029. eric.nestler{at}mssm.edu
  • H. E. Covington III's present address: Department of Psychology and Neuroscience, Duke University, Durham, NC 27708.

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Author contributions

  • H. E. Covington III's present address: Department of Psychology and Neuroscience, Duke University, Durham, NC 27708.

Disclosures

    • Received April 5, 2010.
    • Revision received September 7, 2010.
    • Accepted September 27, 2010.
  • This work was supported by grants from the National Institute of Mental Health, a research alliance with AstraZeneca (E.J.N.), and a NARSAD Young Investigator Award (H.E.C.) from the National Alliance for Research on Schizophrenia and Depression. E.J.N. reports consulting income from Merck Research Laboratories and PsychoGenics, Inc.

  • Correspondence should be addressed to Eric J. Nestler, Fishberg Department of Neuroscience, Mount Sinai School of Medicine, One Gustave L. Levy Place, Box 1065, New York, NY 10029. eric.nestler{at}mssm.edu

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Mar 20215616868
Apr 20214714167
May 20212613974
Jun 20213211366
Jul 2021268449
Aug 2021237635
Sep 2021367963
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Jan 20223310156
Feb 2022387559
Mar 20225511565
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Jul 2022286132
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The Journal of Neuroscience: 30 (48)
Journal of Neuroscience
Vol. 30, Issue 48
1 Dec 2010
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Antidepressant Effect of Optogenetic Stimulation of the Medial Prefrontal Cortex
Herbert E. Covington III, Mary Kay Lobo, Ian Maze, Vincent Vialou, James M. Hyman, Samir Zaman, Quincey LaPlant, Ezekiel Mouzon, Subroto Ghose, Carol A. Tamminga, Rachael L. Neve, Karl Deisseroth, Eric J. Nestler
Journal of Neuroscience 1 December 2010, 30 (48) 16082-16090; DOI: 10.1523/JNEUROSCI.1731-10.2010

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Antidepressant Effect of Optogenetic Stimulation of the Medial Prefrontal Cortex
Herbert E. Covington III, Mary Kay Lobo, Ian Maze, Vincent Vialou, James M. Hyman, Samir Zaman, Quincey LaPlant, Ezekiel Mouzon, Subroto Ghose, Carol A. Tamminga, Rachael L. Neve, Karl Deisseroth, Eric J. Nestler
Journal of Neuroscience 1 December 2010, 30 (48) 16082-16090; DOI: 10.1523/JNEUROSCI.1731-10.2010
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