Antidepressant Effect of Optogenetic Stimulation of the Medial Prefrontal Cortex

Herbert E. Covington; Mary Kay Lobo; Ian Maze; Vincent Vialou; James M. Hyman; Samir Zaman; Quincey LaPlant; Ezekiel Mouzon; Subroto Ghose; Carol A. Tamminga; Rachael L. Neve; Karl Deisseroth; Eric J. Nestler

doi:10.1523/JNEUROSCI.1731-10.2010

Article Information

DOI

https://doi.org/10.1523/JNEUROSCI.1731-10.2010

PubMed

21123555

Published By

Society for Neuroscience

History

Received April 5, 2010
Revision received September 7, 2010
Accepted September 27, 2010
First published December 1, 2010.

Version of record published December 1, 2010.

Author Information

Herbert E. Covington III ¹ ,
Mary Kay Lobo ¹ ,
Ian Maze ¹ ,
Vincent Vialou ¹ ,
James M. Hyman ² ,
Samir Zaman ¹ ,
Quincey LaPlant ¹ ,
Ezekiel Mouzon ¹ ,
Subroto Ghose ³ ,
Carol A. Tamminga ³ ,
Rachael L. Neve ⁴ ,
Karl Deisseroth ⁵ , and
Eric J. Nestler ¹

¹Fishberg Department of Neuroscience, Mount Sinai School of Medicine, New York, New York 10029,
²Department of Psychiatry, University of British Columbia, Vancouver, British Columbia V6T 2B5, Canada,
³Department of Psychiatry, The University of Texas Southwestern Medical Center, Dallas, Texas 75390,
⁴Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, and
⁵Department of Bioengineering, Stanford University, Stanford, California 94305

Correspondence should be addressed to Eric J. Nestler, Fishberg Department of Neuroscience, Mount Sinai School of Medicine, One Gustave L. Levy Place, Box 1065, New York, NY 10029. eric.nestler{at}mssm.edu

H. E. Covington III's present address: Department of Psychology and Neuroscience, Duke University, Durham, NC 27708.

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Author contributions

H. E. Covington III's present address: Department of Psychology and Neuroscience, Duke University, Durham, NC 27708.

Disclosures

Received April 5, 2010.
Revision received September 7, 2010.
Accepted September 27, 2010.

This work was supported by grants from the National Institute of Mental Health, a research alliance with AstraZeneca (E.J.N.), and a NARSAD Young Investigator Award (H.E.C.) from the National Alliance for Research on Schizophrenia and Depression. E.J.N. reports consulting income from Merck Research Laboratories and PsychoGenics, Inc.
Correspondence should be addressed to Eric J. Nestler, Fishberg Department of Neuroscience, Mount Sinai School of Medicine, One Gustave L. Levy Place, Box 1065, New York, NY 10029. eric.nestler{at}mssm.edu

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	Abstract	Full	Pdf
Dec 2010	1798	639	1269
Total 2010	1798	639	1269
Jan 2011	393	400	467
Feb 2011	1026	403	635
Mar 2011	585	242	206
Apr 2011	224	165	137
May 2011	195	2487	145
Jun 2011	936	256	231
Jul 2011	546	108	137
Aug 2011	156	128	123
Sep 2011	86	170	124
Oct 2011	110	212	117
Nov 2011	146	169	160
Dec 2011	112	122	115
Total 2011	4515	4862	2597
Jan 2012	114	148	136
Feb 2012	149	204	152
Mar 2012	172	168	147
Apr 2012	144	135	120
May 2012	128	174	168
Jun 2012	87	164	101
Jul 2012	121	94	75
Aug 2012	88	81	86
Sep 2012	131	116	90
Oct 2012	149	140	91
Nov 2012	171	154	121
Dec 2012	138	112	68
Total 2012	1592	1690	1355
Jan 2013	146	138	109
Feb 2013	123	108	90
Mar 2013	100	119	73
Apr 2013	120	129	90
May 2013	117	121	100
Jun 2013	81	82	74
Jul 2013	69	116	76
Aug 2013	71	489	75
Sep 2013	188	186	63
Oct 2013	128	249	60
Nov 2013	125	706	84
Dec 2013	139	115	88
Total 2013	1407	2558	982
Jan 2014	89	90	83
Feb 2014	97	115	88
Mar 2014	122	110	65
Apr 2014	175	100	87
May 2014	129	122	74
Jun 2014	87	123	61
Jul 2014	133	115	57
Aug 2014	85	57	46
Sep 2014	96	99	51
Oct 2014	160	156	97
Nov 2014	121	120	80
Dec 2014	124	113	62
Total 2014	1418	1320	851
Jan 2015	80	84	56
Feb 2015	106	106	75
Mar 2015	122	92	67
Apr 2015	118	120	70
May 2015	109	101	84
Jun 2015	107	73	60
Jul 2015	84	68	46
Aug 2015	98	54	46
Sep 2015	99	58	69
Oct 2015	121	90	97
Nov 2015	177	134	82
Dec 2015	151	112	81
Total 2015	1372	1092	833
Jan 2016	198	85	107
Feb 2016	118	70	78
Mar 2016	104	77	59
Apr 2016	81	98	40
May 2016	57	105	56
Jun 2016	76	73	40
Jul 2016	71	67	37
Aug 2016	49	50	33
Sep 2016	64	81	32
Oct 2016	45	112	47
Nov 2016	30	118	65
Dec 2016	15	103	60
Total 2016	908	1039	654
Jan 2017	27	131	59
Feb 2017	48	133	43
Mar 2017	62	154	63
Apr 2017	52	110	44
May 2017	32	121	37
Jun 2017	40	104	54
Jul 2017	35	112	39
Aug 2017	36	74	32
Sep 2017	37	95	44
Oct 2017	38	117	48
Nov 2017	48	101	51
Dec 2017	26	93	33
Total 2017	481	1345	547
Jan 2018	40	102	50
Feb 2018	41	109	49
Mar 2018	50	157	68
Apr 2018	43	161	53
May 2018	42	87	44
Jun 2018	25	72	32
Jul 2018	22	73	44
Aug 2018	19	47	20
Sep 2018	27	76	88
Oct 2018	31	135	54
Nov 2018	36	155	53
Dec 2018	32	102	33
Total 2018	408	1276	588
Jan 2019	41	108	53
Feb 2019	40	83	68
Mar 2019	37	119	50
Apr 2019	36	98	57
May 2019	51	87	35
Jun 2019	28	84	27
Jul 2019	20	69	50
Aug 2019	29	80	55
Sep 2019	28	93	27
Oct 2019	48	186	56
Nov 2019	28	74	47
Dec 2019	15	77	30
Total 2019	401	1158	555
Jan 2020	22	77	41
Feb 2020	27	67	30
Mar 2020	26	76	41
Apr 2020	27	114	49
May 2020	30	90	40
Jun 2020	21	69	41
Jul 2020	24	78	45
Aug 2020	27	60	43
Sep 2020	26	77	43
Oct 2020	42	111	78
Nov 2020	49	104	50
Dec 2020	41	102	50
Total 2020	362	1025	551
Jan 2021	34	132	52
Feb 2021	33	102	62
Mar 2021	56	168	68
Apr 2021	47	141	67
May 2021	26	139	74
Jun 2021	12	57	31
Total 2021	208	739	354
Total	14870	18743	11136