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It is my hypothesis that bipolar disorder is caused by an endogenous addiction to testosterone. It is easier to demonstrate in women: http://members.cox.net/jmhoward3/Bipolar%20Disorder.htm .
Lithium reduces testosterone (Hum Exp Toxicol. 2009 Oct;28(10):641- 6). The nucleus accumbens is stimulated by testosterone (Eur Neuropsychopharmacol. 2009 Jan;19(1):53-63).
I suggest the findings of Dzirasa, et al...
It is my hypothesis that bipolar disorder is caused by an endogenous addiction to testosterone. It is easier to demonstrate in women: http://members.cox.net/jmhoward3/Bipolar%20Disorder.htm .
Lithium reduces testosterone (Hum Exp Toxicol. 2009 Oct;28(10):641- 6). The nucleus accumbens is stimulated by testosterone (Eur Neuropsychopharmacol. 2009 Jan;19(1):53-63).
I suggest the findings of Dzirasa, et al., may be explained by reductions in activity in the NA as a result of reductions in testosterone caused by lithium.