Cover legend: Confocal image showing brain-derived adult neural precursor cells (NPCs, turquoise) that express nestin (red). Transplantation of adult NPCs into the chronically injured spinal cord in combination with strategies that optimize the microenvironment of the spinal cord allows functional repair and plasticity after chronic spinal cord injury. For more information, see the article by Karimi-Abdolrezaee et al. in this issue (pages 1657–1676).