Contextual Novelty Changes Reward Representations in the Striatum

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Figure 1.
Experimental design. Trial time line of the test task used during fMRI data acquisition. Beforehand, subjects underwent a familiarization and a conditioning phase inside the scanner but fMRI data were not acquired.
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Figure 2.
fMRI results. A, Results of the contrast novel versus familiar in the hippocampus ROI, and parameter estimate at the peak voxel of the activated cluster displayed in the map. B, Results of the contrast high reward probability (p = 0.8) versus no reward (p = 0) in the midbrain ROI, and parameter estimate at the peak voxel of the activated cluster displayed in the map. C, Results of the contrast high reward probability versus no reward in the striatum ROI, and parameter estimate at the peak voxel of the three activated clusters displayed in the map. Data are thresholded at p < 0.05 FDR. Activation maps are superimposed to on a T₁ group template (A, C) and on an MT group template.

Table 1.

fMRI results: details of fMRI activations within the hippocampus, the striatum, and the midbrain ROI

	Voxel size	FDR	t	z	MNI peak coordinates (mm)
	Voxel size	FDR	t	z	x	y	z
Novel versus familiar
Hippocampus	13	0.011	4.28	4.04	22	−14	−26
		0.011	4.28	4.04	24	−20	−18
	14	0.015	4.07	3.85	−24	−26	−10
	10	0.017	3.98	3.78	−22	−18	−20
Striatum	49	0.002	5.16	4.76	16	10	−2
	21	0.013	4.06	3.85	−6	10	0
	18	0.015	3.93	3.73	−16	8	0
	13	0.019	3.77	3.6	26	4	−2
	25	0.022	3.6	3.45	10	16	−2
	10	0.025	3.48	3.34	28	−6	0
High reward probabilityversus no reward
Midbrain	6	0.003	4.42	4.16	−8	−14	−8
Striatum	53	0.002	5.26	4.83	−10	14	2
		0.034	3.08	2.98	−10	6	6
	55	0.008	4.4	4.14	−22	4	0
		0.011	4	3.79	−24	10	−6
	30	0.009	4.18	3.95	8	10	0