CX3CR1 in Microglia Regulates Brain Amyloid Deposition through Selective Protofibrillar Amyloid-β Phagocytosis

Zhiqiang Liu; Carlo Condello; Aaron Schain; Roa Harb; Jaime Grutzendler

doi:10.1523/JNEUROSCI.4403-10.2010

Article Information

DOI

https://doi.org/10.1523/JNEUROSCI.4403-10.2010

PubMed

21159979

Published By

Society for Neuroscience

History

Received August 21, 2010
Revision received October 4, 2010
Accepted October 21, 2010
Published in print December 15, 2010.

Author Information

Zhiqiang Liu¹,*,
Carlo Condello¹,*,
Aaron Schain¹,*,
Roa Harb¹, and
Jaime Grutzendler¹,²

¹Departments of Neurology and
²Physiology, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611

Correspondence should be addressed to Jaime Grutzendler, Departments of Neurology and Physiology, Northwestern University Feinberg School of Medicine, 303 East Chicago Avenue, Ward 10-132, Chicago, IL 60611. grutzj{at}northwestern.edu

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Author contributions

↵*Z.L., C.C., and A.S. contributed equally to this work.

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Disclosures

Received August 21, 2010.
Revision received October 4, 2010.
Accepted October 21, 2010.

This work was supported by National Institutes of Health–National Institute on Aging Grant R01 AG027855 (J.G.), Ellison Medical Foundation New Scholar Award in Aging (J.G.), and Dana Foundation Brain and Immunoimaging Award (J.G.).
Correspondence should be addressed to Jaime Grutzendler, Departments of Neurology and Physiology, Northwestern University Feinberg School of Medicine, 303 East Chicago Avenue, Ward 10-132, Chicago, IL 60611. grutzj{at}northwestern.edu

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	Abstract	Full	Pdf
Dec 2010	410	164	372
Total 2010	410	164	372
Jan 2011	128	150	182
Feb 2011	64	117	89
Mar 2011	115	105	73
Apr 2011	80	163	65
May 2011	79	53	47
Jun 2011	44	49	32
Jul 2011	35	57	44
Aug 2011	53	56	44
Sep 2011	75	68	55
Oct 2011	48	87	72
Nov 2011	40	68	55
Dec 2011	52	45	40
Total 2011	813	1018	798
Jan 2012	42	57	31
Feb 2012	64	50	43
Mar 2012	59	49	25
Apr 2012	58	39	28
May 2012	52	41	30
Jun 2012	23	32	25
Jul 2012	36	35	27
Aug 2012	20	33	35
Sep 2012	38	28	31
Oct 2012	26	29	28
Nov 2012	46	32	48
Dec 2012	45	38	44
Total 2012	509	463	395
Jan 2013	37	45	31
Feb 2013	35	34	443
Mar 2013	40	47	27
Apr 2013	37	43	29
May 2013	34	38	46
Jun 2013	19	29	24
Jul 2013	20	25	25
Aug 2013	21	23	29
Sep 2013	20	20	20
Oct 2013	32	31	24
Nov 2013	43	42	35
Dec 2013	30	40	19
Total 2013	368	417	752
Jan 2014	32	33	14
Feb 2014	17	35	31
Mar 2014	22	26	24
Apr 2014	40	33	37
May 2014	24	24	27
Jun 2014	23	18	16
Jul 2014	29	36	14
Aug 2014	20	35	16
Sep 2014	44	32	23
Oct 2014	53	31	14
Nov 2014	33	22	13
Dec 2014	21	18	10
Total 2014	358	343	239
Jan 2015	37	27	15
Feb 2015	17	22	16
Mar 2015	32	29	23
Apr 2015	24	23	18
May 2015	22	54	16
Jun 2015	16	47	13
Jul 2015	26	57	23
Aug 2015	13	11	19
Sep 2015	21	19	10
Oct 2015	25	14	15
Nov 2015	25	17	11
Dec 2015	27	17	9
Total 2015	285	337	188
Jan 2016	59	25	15
Feb 2016	25	19	24
Mar 2016	39	23	20
Apr 2016	26	26	22
May 2016	16	26	21
Jun 2016	25	27	28
Jul 2016	21	22	18
Aug 2016	18	32	16
Sep 2016	26	19	14
Oct 2016	20	36	24
Nov 2016	14	30	14
Dec 2016	5	32	26
Total 2016	294	317	242
Jan 2017	7	37	12
Feb 2017	4	40	15
Mar 2017	8	53	16
Apr 2017	13	44	49
May 2017	4	49	18
Jun 2017	2	24	10
Jul 2017	7	28	16
Aug 2017	8	27	6
Sep 2017	12	34	13
Oct 2017	7	43	18
Nov 2017	4	56	23
Dec 2017	7	39	11
Total 2017	83	474	207
Jan 2018	13	48	14
Feb 2018	3	46	26
Mar 2018	3	63	21
Apr 2018	9	43	10
May 2018	8	44	15
Jun 2018	10	43	10
Jul 2018	10	42	24
Aug 2018	5	37	11
Sep 2018	6	38	14
Oct 2018	6	41	18
Nov 2018	2	37	16
Dec 2018	6	73	13
Total 2018	81	555	192
Jan 2019	7	45	22
Feb 2019	5	49	22
Mar 2019	13	50	33
Apr 2019	6	58	20
May 2019	7	47	12
Jun 2019	11	55	20
Jul 2019	12	62	22
Aug 2019	8	95	25
Sep 2019	11	101	19
Oct 2019	6	122	15
Nov 2019	6	34	10
Dec 2019	1	9	3
Total 2019	93	727	223
Total	3294	4815	3608