Articles, Cellular/Molecular

NAD+ Depletion Is Necessary and Sufficient forPoly(ADP-Ribose) Polymerase-1-Mediated Neuronal Death

Conrad C. Alano, Philippe Garnier, Weihai Ying, Youichirou Higashi, Tiina M. Kauppinen and Raymond A. Swanson
Journal of Neuroscience 24 February 2010, 30 (8) 2967-2978; https://doi.org/10.1523/JNEUROSCI.5552-09.2010

Article Information

DOI 
https://doi.org/10.1523/JNEUROSCI.5552-09.2010
PubMed 
20181594
Published By 
Society for Neuroscience
History 
  • Received November 10, 2009
  • Revision received December 17, 2009
  • Accepted December 24, 2009
  • First published February 24, 2010.
  • Version of record published February 24, 2010.
Copyright & Usage 
Copyright © 2010 the authors 0270-6474/10/302967-12$15.00/0

Author Information

  1. Conrad C. Alano,
  2. Philippe Garnier,
  3. Weihai Ying,
  4. Youichirou Higashi,
  5. Tiina M. Kauppinen, and
  6. Raymond A. Swanson
  1. Department of Neurology, University of California, San Francisco, and San Francisco Veterans Affairs Medical Center, San Francisco, California 94121
  1. Correspondence should be addressed to Dr. Conrad C. Alano, Department of Neurology (127), Veterans Affairs Medical Center, 4150 Clement Street, San Francisco, CA 94121. conrad.alano{at}ucsf.edu

  • P. Garnier's present address: Laboratoire Inserm Unité 887 Motricité-Plasticité, Faculté de Pharmacie, 7 Boulevard Jeanne d'Arc, BP 87900, 21079 Dijon, France.

  • W. Ying's present address: Med-X Research Institute, Shanghai Jiaotong University, 1954 Huashan Road, Shanghai 200030, Shanghai, China.

  • Y. Higashi's present address: Department of Neurosurgery, Medical School, Koch University, Kohasu, Okou-cho, Kochi 783-8505, Japan.

View Full Text

Author contributions

  • P. Garnier's present address: Laboratoire Inserm Unité 887 Motricité-Plasticité, Faculté de Pharmacie, 7 Boulevard Jeanne d'Arc, BP 87900, 21079 Dijon, France.

  • W. Ying's present address: Med-X Research Institute, Shanghai Jiaotong University, 1954 Huashan Road, Shanghai 200030, Shanghai, China.

  • Y. Higashi's present address: Department of Neurosurgery, Medical School, Koch University, Kohasu, Okou-cho, Kochi 783-8505, Japan.

Disclosures

    • Received November 10, 2009.
    • Revision received December 17, 2009.
    • Accepted December 24, 2009.

  • This work was supported by National Institutes of Health Grant NS14543 (R.A.S.), the Department of Veterans Affairs (C.C.A., R.A.S., W.Y.), and the American Heart Association (C.C.A.).

  • Correspondence should be addressed to Dr. Conrad C. Alano, Department of Neurology (127), Veterans Affairs Medical Center, 4150 Clement Street, San Francisco, CA 94121. conrad.alano{at}ucsf.edu

Online Impact

 

Article usage

Article usage: January 2018 to November 2025

AbstractFullPdf
Jan 201823814
Feb 20184288
Mar 201823011
Apr 201824414
May 20185378
Jun 20182258
Jul 201843214
Aug 20180348
Sep 201825315
Oct 20180357
Nov 201813613
Dec 201893612
Total 201833428132
Jan 201953220
Feb 201976216
Mar 201953514
Apr 20194308
May 201964417
Jun 201963512
Jul 20197199
Aug 201963124
Oct 2019815413
Nov 201943211
Dec 201911347
Total 201969508151
Jan 202094510
Feb 202033520
Mar 202072712
May 202085524
Jun 202052312
Jul 202073418
Aug 20202289
Sep 202064323
Oct 202035629
Nov 202076123
Dec 202064513
Total 202063452193
Jan 202115417
Feb 202116315
Mar 202156625
Apr 202137731
May 202117925
Jun 202115128
Jul 202103314
Aug 202125414
Sep 202135316
Oct 202148229
Nov 202135418
Dec 202106420
Total 202124730252
Jan 202204918
Feb 202225021
Mar 202227221
Apr 202206528
May 202254335
Jun 202216339
Jul 202214018
Aug 202224719
Sep 202229325
Oct 2022210646
Nov 202213810
Dec 20221438
Total 202219709288
Jan 2023310525
Feb 202326421
Mar 202308417
Apr 202345019
May 202323916
Jun 202324713
Jul 202334028
Aug 202325320
Sep 2023014515
Oct 2023330613
Nov 2023552817
Dec 202318516
Total 2023271546220
Jan 2024311911
Feb 2024112320
Mar 202418019
Apr 2024525034
May 202446515
Jun 202424412
Jul 202424512
Aug 202425615
Sep 20244459
Oct 20241235726
Nov 20241413229
Dec 2024109226
Total 2024601408228
Jan 202567424
Feb 20251211015
Mar 202579420
Apr 202546814
May 202557214
Jun 202576520
Jul 202587128
Aug 2025137722
Sep 2025118130
Oct 202559030
Nov 20250206
Total 202578822223
Total37366031687
Back to top

In this issue

Email
Print
View Full Page PDF
Citation Tools
Respond to this article
NAD+ Depletion Is Necessary and Sufficient forPoly(ADP-Ribose) Polymerase-1-Mediated Neuronal Death
Conrad C. Alano, Philippe Garnier, Weihai Ying, Youichirou Higashi, Tiina M. Kauppinen, Raymond A. Swanson
Journal of Neuroscience 24 February 2010, 30 (8) 2967-2978; DOI: 10.1523/JNEUROSCI.5552-09.2010
Twitter logo Facebook logo Mendeley logo

Jump to section

Responses to this article

Respond to this article

Jump to comment:

No eLetters have been published for this article.